Serum Proteome Pool Changes in Type 2 Diabetic Patients Treated with Anakinra

Table 1 Biomarkers potentially useful as surrogates for clinical outcome

Peak (Da)	Protein identity	Biomarker change at 13 weeks	p value for responder^a (n = 21, Wilcoxon)	p value for responder^a (n = 21, permutation test)
2,740	Unknown	Up	0.016	0.009
7,048	Unknown	Up	0.022	0.011
13,752	Transthyretin	Up	0.002	0.001
13,944	Transthyretin (modified)	Up	0.006	0.004
14,089	Transthyretin (modified)	Up	0.004	0.003
14,300	Transthyretin (modified)	Up	0.001	0.001
14,507	Transthyretin (modified)	Up	0.001	0.001
14,758	Transthyretin (modified)	Up	<0.001	0.001
27,788	Transthyretin (dimer)	Up	0.013	0.007
39,866	Unknown	Up	0.042	0.021
56,878	Unknown	Up	0.004	0.003
79,628	Transferrin	Up	0.042	0.021

^aResponse was defined as any reduction in HbA_1c during the 13 week of intervention

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