Serum Proteome Pool Changes in Type 2 Diabetic Patients Treated with Anakinra

Table 2 Proteins altering concentration due to anakinra treatment

Peak (Da)	Protein identity	Biomarker change at 13 weeks	P value for treated^a (n = 34, Wilcoxon)	p value for treated^a (n = 34, permutation test)
7,042	Unknown	Up	0.050	0.025
8,208	Unknown	Up	0.025	0.013
20,990	Unknown	Up	0.009	0.005
21,086	RBP4	Up	0.017	0.009
21,278	RPB4 (modified)	Up	0.043	0.021
28,601	Apo-A1^b (modified)	Up	0.007	0.004

^aThe treated patients received daily subcutaneous injections with 100 mg of anakinra for 13 weeks
^bThe final identity of the 28,601 Da protein as being modified apo-AI has not been definitively established; the preliminary identity is based on the mass and similarity to Western blot findings

ISSN: 1559-0275