Comparative Proteomic Analysis of Candida albicans and Candida glabrata

Prasad, Thottethodi Subrahmanya Keshava; Keerthikumar, Shivakumar; Chaerkady, Raghothama; Kandasamy, Kumaran; Renuse, Santosh; Marimuthu, Arivusudar; Venugopal, Abhilash Karavattu; Thomas, Joji Kurian; Jacob, Harrys K. C.; Goel, Renu; Pawar, Harsh; Sahasrabuddhe, Nandini A.; Krishna, Venkatarangaiah; Nair, Bipin G.; Gucek, Marjan; Cole, Robert N.; Ravikumar, Raju; Harsha, H. C.; Pandey, Akhilesh

doi:10.1007/s12014-010-9057-9

Clinical Proteomics

Table 2 A partial list of proteins with higher levels of expression in Candida glabrata

From: Comparative Proteomic Analysis of Candida albicans and Candida glabrata

	Gene IDs	Protein name	Relative expression (C. glabrata/C. albicans)	Common tryptic peptides (≤95% confidence)	Common tryptic peptides (≥95% confidence)
1	3640000	Likely cobalamin-independent methionine synthase Met6 [C. albicans]	1.51	ALDADVVSIEFSK,FWVNPDCGLK	–
1	2889085	Hypothetical protein CAGL0I04994g [C. glabrata]	1.51	ALDADVVSIEFSK,FWVNPDCGLK	–
2	3641547	Likely adenylylsulfate kinase Met14 [C. albicans]	1.53	DLGFSEADRNENIR	–
2	2890901	Hypothetical protein CAGL0L02321g [C. glabrata]	1.53	DLGFSEADRNENIR	–
3	3640659	Adenosine triphosphatase Pma1 [C. albicans]	1.54	GYLVAMTGDGVNDAPSLK, SAADIVFLAPGLSAIIDALK, GAPLFVLK, KQAIVQK	KGLDAIDK
3	2886465	Hypothetical protein CAGL0A00495g [C. glabrata]	1.54	GYLVAMTGDGVNDAPSLK, SAADIVFLAPGLSAIIDALK, GAPLFVLK, KQAIVQK	KGLDAIDK
4	3642461	Likely 26 S proteasome regulatory particle ATPase Rpt1 [C. albicans]	1.57	KVEFSLPDLEGR	VIGSELVQKYVGEGAR, YVGEGARMVRELFEMAR
4	2887298	Hypothetical protein CAGL0E06490g [C. glabrata]	1.57	KVEFSLPDLEGR	VIGSELVQKYVGEGAR, YVGEGARMVRELFEMAR
5	3644290	Mitochondrial ketol-acid reductoisomerase Ilv5 [C. albicans]	1.60	TLYFSHGFSPVFK, DNGLNVIIGVR, YGMDYMYDACSTTAR	–
5	2886604	Hypothetical protein CAGL0B03047g [C. glabrata]	1.60	TLYFSHGFSPVFK, DNGLNVIIGVR, YGMDYMYDACSTTAR	–
6	3647367	Histone H3 Hht2 [C. albicans]	1.72	KSAPSTGGVK, YKPGTVALR	QTARKSTGGK, KSTGGK, STGGKAPR, KQLASK, KLPFQR
6	2886846	Hypothetical protein CAGL0M06655g [C. glabrata]	1.72	KSAPSTGGVK, YKPGTVALR	QTARKSTGGK, KSTGGK, STGGKAPR, KQLASK, KLPFQR
7	3637507	Heat shock protein Hsp90 [C. albicans]	2.10	GVVDSEDLPLNLSR,SPFLDALK	EDQLEYLEEK, TKPLWTR, KNNIK
7	2891108	Hypothetical protein CAGL0L00495g [C. glabrata]	2.10	GVVDSEDLPLNLSR,SPFLDALK	EDQLEYLEEK, TKPLWTR, KNNIK
8	3644934	Cytosolic NADP-specific isocitrate dehydrogenase Idp2 [C. albicans]	2.24	NILGGTVFR, CATITPDEAR, LIDDMVAQMLK	–
8	2886496	Hypothetical protein CAGL0B04917g [C. glabrata]	2.24	NILGGTVFR, CATITPDEAR, LIDDMVAQMLK	–
9	3647488	Mitochondrial NADP-specific isocitrate dehydrogenase Idp1 [C. albicans]	2.36	CATITPDEAR, NILGGTVFR	–
9	2887212	Hypothetical protein CAGL0D00770g [C. glabrata]	2.36	CATITPDEAR, NILGGTVFR	–
10	3639407	Beta-tubulin Tub2 [C. albicans]	2.44	KLAVNLVPFPR, LAVNLVPFPR	–
10	2890421	Hypothetical protein CAGL0K12650g [C. glabrata]	2.44	KLAVNLVPFPR, LAVNLVPFPR	–

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ISSN: 1559-0275

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