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Table 6 The 17-urine-peptide SJIA biomarkers were found to be degradation products of eight different proteins

From: Urine Peptidomic and Targeted Plasma Protein Analyses in the Diagnosis and Monitoring of Systemic Juvenile Idiopathic Arthritis

Protein

m/z

U test P value

Peptide sequence

ND/SAF vs. KD

ND/SAF vs. FI

ND/SAF vs. AF

ND/SAF vs. QOM

ND/SAF vs. RD

ND/SAF vs. HC

A1AT

1,796.96

3.87E − 02*

9.74E − 04**

1.67E − 03**

2.57E − 03**

2.97E − 03**

1.35E − 03**

EAIPMSIPPEVKFNKP

Cluster I

A1AT

1,945.98

1.24E − 02*

5.91E − 04**

1.37E − 03**

7.26E − 04**

2.04E − 03**

1.35E − 03**

EAIPMSIPPEVKFNKPF

COL1A1

1,570.73

1.15E − 02*

2.94E − 03**

9.45E − 01

2.06E − 01

6.60E − 01

6.73E − 02

GAKGDAGApGApGSQGApG

 

COL1A1

1,580.71

1.99E − 07**

7.24E − 04**

2.01E − 02*

8.54E − 03*

4.25E − 03**

8.22E − 02

SpGSpGPDGKTGPPGpAG

 

COL1A1

1,734.8

6.56E − 02

5.54E − 02

4.36E − 02*

2.51E − 01

2.95E − 01

9.48E − 01

GPpGPpGKNGDDGEAGKPG

Cluster II

COL1A1

1,810.89

3.42E − 02*

1.42E − 01

3.90E − 01

3.03E − 01

2.01E − 02*

8.22E − 02

GPpGKNGDDGEAGKpGRpG

COL1A1

2,408.07

3.69E − 05**

1.35E − 01

1.75E − 02*

8.73E − 02

5.98E − 03*

2.16E − 02*

NGDDGEAGKPGRpGERGPpGP

COL1A2

1,853.79

2.50E − 01

1.95E − 01

2.53E − 01

2.22E − 02*

6.27E − 01

5.02E − 01

NGApGEAGRDGNpGNDGPpG

 

COL3A1

1,624.73

1.43E − 03**

6.23E − 03*

5.32E − 01

9.90E − 02

3.65E − 01

9.48E − 01

DGApGKNGERGGpGGpGP

 

COL9A2

1,126.49

3.14E − 04**

8.66E − 07**

2.97E − 03**

6.43E − 03*

1.83E − 01

2.48E − 01

PpGPpGYPGKQ

 

FGA

1,826.79

3.01E − 02*

1.35E − 01

9.45E − 01

2.06E − 01

1.99E − 01

2.31E − 01

DEAGSEADHEGTHSTKR

Cluster III

FGA

1,883.8

4.14E − 03**

5.91E − 04**

3.17E − 01

1.03E − 02*

3.86E − 02*

7.18E − 03*

DEAGSEADHEGTHSTKRG

FGB

1,631.83

2.26E − 03**

1.43E − 03**

1.37E − 03**

1.26E − 01

1.27E − 01

4.22E − 01

EEAPSLRPAPPPISGGG

Cluster IV

FGB

1,794.9

5.86E − 02

4.50E − 03**

9.69E − 03*

3.53E − 03**

4.25E − 03**

1.90E − 02*

EEAPSLRPAPPPISGGGY

UMOD

982.58

4.24E − 07**

1.60E − 04**

9.08E − 01

1.96E − 01

2.34E − 01

1.00E + 00

VLNLGPITR

Cluster V

UMOD

1,654.91

4.47E − 01

4.05E − 01

4.25E − 03**

3.31E − 01

1.13E − 02*

6.81E − 01

SGSVIDQSRVLNLGPI

UMOD

1,755.95

5.33E − 04**

3.50E − 03**

2.31E − 02*

2.64E − 01

1.40E − 01

1.69E − 01

SGSVIDQSRVLNLGPIT

  1. The Mann–Whitney U tests were performed to evaluate the significance of discriminations between disease classes, as indicated, and between active systemic disease (ND/SAF) and healthy control (HC) samples
  2. *0.005 < P value < 0.05; **P value < 0.005
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Clinical Proteomics

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