Table 1 Partial list of proteins overexpressed in serum samples of chikungunya patients
| Â | Protein | Gene symbol | RefSeq accession | Description | Fold change (chikungunya/control) |
|---|---|---|---|---|---|
1 | SH3 and PX domain-containing protein 2B | DLST | NP_001017995.1 | It is an adapter protein and is involved in cell adhesion and migration of numerous cell types. It interacts with Fas-ligand, which is a cytotoxic effector molecule of T and NK cells. | 6 |
2 | Optineurin | OPTN | NP_001008214.1 | It is a coiled-coil containing protein that interacts with viral protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. | 5 |
3 | Spermine synthase | SMS | NP_004586.2 | Its deficiency is shown to impair neurodevelopment and cognitive ability. | 5 |
4 | Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial | SUCLA2 | NP_003841.1 | It is a mitochondrial matrix enzyme that hydrolyzes ATP to convert succinate to succinyl-CoA. | 4 |
5 | Apolipoprotein A-IV | APOA4 | NP_000473.2 | Apolipoproteinis an activator of lecithin-cholesterol acyltransferase. | 4 |
6 | Apolipoprotein C-I | APOC1 | NP_001636.1 | It is known to be activated upon differentiation of monocytes to macrophages. | 4 |
7 | Probable ATP-dependent RNA helicase DDX23 | DDX23 | NP_004809.2 | It is a component of the U5 snRNP complex and has been reported to be upregulated upon induction of viral replication. | 3 |
8 | Haptoglobin isoform 1 preproprotein | HP | NP_005134.1 | Haptoglobin binds to free plasma hemoglobin, and enables hemoglobin degradation. It also prevents loss of iron through kidneys and protects damage of kidneys from hemoglobin. | 3 |
9 | Glutamyl aminopeptidase | ENPEP | NP_001968.3 | It is an aminopeptidase and is involved in the regulation of blood pressure. | 2 |
10 | Clusterin | CLU | NP_001822.3 | It is a secreted chaperone. It is known to be involved in events such as cell death and neurodegenerative disorders. | 2 |