Table 2 Partial list of proteins downregulated in serum samples of chikungunya infected patients
| Â | Protein | Gene symbol | RefSeq accession | Description | Fold change (control/ chikungunya) |
|---|---|---|---|---|---|
1 | Azurocidin preproprotein | AZU1 | NP_001691.1 | It is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. | 2 |
2 | Peroxiredoxin-2 isoform a | PRDX2 | NP_005800.3 | It plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8 (+) T-cells. | 2 |
3 | Annexin A1 | ANXA1 | NP_000691.1 | It is a calcium-dependent phospholipid binding proteins with potential anti-inflammatory activity. | 3 |
4 | Lipocalin-1 isoform 1 | LCN1 | NP_002288.1 | Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. Lipocalins are overproduced in response to multiple stimuli including infection and stress. | 4 |
5 | Protein S100-A9 | S100A9 | NP_002956.1 | It is a calcium-binding protein and a member of the S100 family, involved in the regulation of cell cycle progression and differentiation. | 4 |
6 | Neutrophil elastase preproprotein | ELANE | NP_001963.1 | It is a serine protease, which hydrolyzes proteins within azurophil granules and that of extracellular matrix following the protein’s release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases. | 5 |
7 | Myeloblastin | PRTN3 | NP_002768.3 | It is a serine protease found in the azurophilic granules in neutrophil granulocytes. | 6 |
8 | Cathepsin G preproprotein | CTSG | NP_001902.1 | It is a member of the peptidase S1 protein family and is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. It may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. | 6 |
9 | Protein S100-A7 | S100A7 | NP_002954.2 | It is a member of S100 family of proteins but lacks calcium binding ability. It is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. | 7 |
10 | Phosphatidylinositide phosphatase SAC1 | SACM1L | NP_054735.3 | Sac1 is a phosphoinositide lipid phosphatase that removes the phosphate residue from the inositol head group of PI(4)P. | 16 |