Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring

Table 1 Seven glycopeptide signature for MPM in serum

MPM candidate biomarker N-glycopeptides monitored by SRM*	Protein name	UniProt/Swiss-Prot entry	Gene name	ng/ml**
ADLTVVLLR	Intercellular adhesion molecule 1	P05362	ICAM1	71
ALVDFTR	Basement membrane-specific heparan sulfate proteoglycan core protein	P98160	HSPG2	120
DFDETQLAR	Anthrax toxin receptor 1	Q9H6X2	ANTXR1	Not available
HADWTLTPLK	Serum paraoxonase/arylesterase 1	P27169	PON1	22' 000
VIDETWAWK	Hypoxia up-regulated protein 1	Q9Y4L1	HYOU1	6.6
VVDSTTGPGEHLR	Thrombospondin-1	P07996	THBS1	510
KWDVTSLETLK	Mesothelin	Q13446	MSLN	Not available

*D replaces the former glycosylated N in the natural peptide sequence after deamidation induced by PNGaseF treatment.
**Concentration in serum/plasma as estimated in PeptideAtlas (ref. Farrah et al. [32]).

ISSN: 1559-0275