Figure 2
From: Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis
Validation of upregulated proteins by ELISA and CHIT-1 activity assay. Chitotriosidase was found to be 17 fold upregulated (**p < 0.01 vs. N-CSF; A) and chitinase 3- like-2 (CHI3L2) showed ~2 fold increase (**p < 0.01 vs. N-CSF; B) in ALS-CSF. Osteopontin showed ~ 1.9 fold upregulation (*p < 0.05 vs. N-CSF; C) whereas, upregulation in Chitinase 3- like-1 (CHI3L1) levels was statistically non- significant (D). Histogram showing CHIT-1 enzymatic activity in CSF samples. The activity was found to be 10 fold higher in ALS-CSF (**p < 0.001 vs. N-CSF; E).