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Table 1 Proteins that show decreased expression in T21 amniocytes (n = 29)

From: Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome

Gene name

Protein name

Ratio (H/L)1

AKAP12

A-kinase anchor protein 12

0.41

APOA1

Apolipoprotein A-I

0.07

APOC3

Apolipoprotein C-III variant 1

0.12

ARHGEF2

Rho guanine nucleotide exchange factor 2

0.52

CNBP

cDNA FLJ77718

0.42

CTRB1

cDNA FLJ77335, highly similar to Homo sapiens chymotrypsinogen B1 (CTRB1), mRNA

0.12

ERC1

ELKS/RAB6-interacting/CAST family member 1

0.63

FBLIM1

Filamin-binding LIM protein 1

0.62

FHL3

Four and a half LIM domains protein 3

0.59

HMGA2

HMGA2e

0.52

HPX

Hemopexin

0.22

ICAM1

Intercellular adhesion molecule 1

0.62

IGF2R

Cation-independent mannose-6-phosphate receptor

0.65

LTF

Lactotransferrin

0.05

MARCKSL1

MARCKS-related protein

0.58

MCAM

Cell surface glycoprotein MUC18

0.45

NES

NES protein

0.18

NUBP1

Nucleotide-binding protein 1

0.30

PCK2

cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32)

0.57

PGPEP1

Pyroglutamyl-peptidase 1

0.65

POSTN

Periostin

0.25

PPIF

Peptidyl-prolyl cis-trans isomerase, mitochondrial

0.20

PZP

Pregnancy zone protein

0.11

SDCBP

Syndecan binding protein (Syntenin)

0.46

SLC2A1

Solute carrier family 2, facilitated glucose transporter member 1

0.52

SOLO

Protein SOLO

0.39

TAF15

TATA-binding protein-associated factor 2N

0.39

TNS1

Tensin-1

0.57

TRIP6

Thyroid receptor-interacting protein 6

0.64

  1. 1. Heavy/light ratio with SILAC method, calculated as the average of three experimental pairs when available. Only proteins which showed decreased ratio for different peptides, as well as consistency in the pattern of expression of experimental pairs were selected.