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Table 1 Functional classification of proteins common in all PPDs

From: Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis

  Gene symbol Description Function Reference
1 AcpP Acyl carrier protein It shuttles the intermediates between the enzymes of type II fatty acid synthase system [31]
2 FbpA Secreted antigen 85-A It participates in cell wall biosynthesis, and interacts with the host macrophage as fibronectin-binding protein. It is also involved in establishment and maintenance of a persistent tuberculosis infection [32, 33]
3 GroES Co-chaperonin It is a dominant immunogenic protein [34]
4 DnaK Molecular chaperone It is highly antigenic and act as co-repressors for heat shock protein transcriptional repressor (hspR) [35]
5 Tpx Thiol peroxidase It protects M. tuberculosis against oxidative and nitrosative stress [36]
6 RpiL 50S ribosomal protein L7/L12 It is involved in interaction with translation factors [37]
7 BfrA Bacterioferritin It is an intracellular iron storage protein, which protects Mycobacterium from oxidative stress mediated by excess iron [38]
8 SahH S-adenosyl-L-homocysteine hydrolase It is a ubiquitous enzyme that plays a central role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine (SAH) and S-adenosylmethionine [39]
9 TrxC Thioredoxin It is involved in redox homeostasis and uses it to protect the pathoen against the oxidative intermediates generated by the macrophages [40]
10 FixB Electron transfer flavoprotein subunit alpha It is electron transfer flavoprotein subunit alpha, in some bacteria it functions as nitrogen fixing agent but its function in M .tuberculosis is not clear [41]
11 PepA Serine protease It is a serine protease associated with cell membrane, which stimulates peripheral blood mononuclear cells from healthy PPD donors to proliferate and secrete gamma interferon [42]
12 Wag31 Hypothetical protein It is a cell division initiation protein involved in regulation of genes including virulence factors and antigens [43]
13 Mpt64 Hypothetical protein It is an immunogenic protein which elicits delayed type hypersensitivity skin response [44]
14 Apa Alanine and proline rich secreted protein It is a cell surface glycoprotein which binds to host lectins and cheat the innate immune system [45]
15 LprG Lipoprotein LprG It plays a role in M. tuberculosis infection by inducing increased suppression of the immune response due to elevated nitric oxide production [46]
16 Rv1893 Hypothetical protein Function unknown [47]
17 Rv1855c Oxidoreductase Probable monooxygenase [48]
18 Gap Glyceraldehyde-3-phosphate dehydrogenase It has glyceraldehyde-3-phosphate dehydrogenase activity [49]