Table 2 A partial list of novel proteins upregulated in OA
| Â | Gene symbol | Protein | Molecular function | Cellular component | Fold change (OA/RA) |
|---|---|---|---|---|---|
1 | CRISP3 | Cysteine-rich secretory protein 3 | Extracellular matrix structural constituent | Secretory granule | 5.0 |
2 | TTK | TTK protein kinase | Protein threonine/tyrosine kinase activity | Centrosome | 5.0 |
3 | NOTCH4 | Notch 4 | Receptor activity | Plasma membrane | 5.0 |
4 | CD5L | CD5 molecule-like | Defense/immunity protein activity | Extracellular | 3.3 |
5 | COL15A1 | Collagen, type XV, alpha 1 | Extracellular matrix structural constituent | Extracellular | 3.3 |
6 | SSC5D | Scavenger receptor cysteine rich domain containing (5 domains) | Molecular function unknown | - | 3.3 |
7 | RTN4RL2 | Reticulon 4 receptor-like 2 | Receptor activity | Plasma membrane | 3.3 |