Skip to main content

Table 2 “Normal Pap test Core Proteome,” defined as the 153 proteins that were identified by MS/MS in the residual Pap test fluid from 4 out of 5 women with normal cytology

From: A feasibility study to identify proteins in the residual Pap test fluid of women with normal cytology by mass spectrometry-based proteomics

 

Identified proteins

Gene name

Accession number

Present in CVF Core Proteome*

Present in at least one other CVF Proteome study**

1

14-3-3 protein epsilon

YWHAE

[Swiss-Prot: P62258]

 

X

2

14-3-3 protein zeta/delta

YWHAZ

[Swiss-Prot: P63104]

√

 

3

40S ribosomal protein S16

RPS16

[Swiss-Prot: P62249]

 

X

4

78 kDa glucose-regulated protein

HSPA5

[Swiss-Prot: P11021]

√

 

5

Acid ceramidase

ASAH1

[Swiss-Prot: Q13510]

  

6

Actin, cytoplasmic 1

ACTB

[Swiss-Prot: P60709]

√

 

7

Acylamino-acid-releasing enzyme

APEH

[Swiss-Prot: P13798]

  

8

Adenylate kinase 2, mitochondrial

AK2

[Swiss-Prot: P54819]

  

9

Afamin

AFM

[Swiss-Prot: P43652]

 

X

10

Alpha-1-antitrypsin

SERPINA1

[Swiss-Prot: P01009]

√

 

11

Alpha-1B-glycoprotein

A1BG

[Swiss-Prot: P04217]

 

X

12

Alpha-2-HS-glycoprotein

AHSG

[Swiss-Prot: P02765]

√

 

13

Alpha-2-macroglobulin

A2M

[Swiss-Prot: P01023]

 

X

14

Alpha-actinin-1

ACTN1

[Swiss-Prot: P12814]

 

X

15

Alpha-actinin-4

ACTN4

[Swiss-Prot: O43707]

√

 

16

Alpha-enolase

ENO1

[Swiss-Prot: P06733]

√

 

17

Annexin A1

ANXA1

[Swiss-Prot: P04083]

√

 

18

Annexin A11

ANXA11

[Swiss-Prot: P50995]

 

X

19

Annexin A2

ANXA2

[Swiss-Prot: P07355]

√

 

20

Annexin A3

ANXA3

[Swiss-Prot: P12429]

√

 

21

Annexin A5

ANXA5

[Swiss-Prot: P08758]

 

X

22

Apolipoprotein D

APOD

[Swiss-Prot: P05090]

 

X

23

Aspartate aminotransferase, cytoplasmic

GOT1

[Swiss-Prot: P17174]

 

X

24

Aspartate aminotransferase, mitochondrial

GOT2

[Swiss-Prot: P00505]

  

25

Beta-2-glycoprotein 1

APOH

[Swiss-Prot: P02749]

√

 

26

Brain acid soluble protein 1

BASP1

[Swiss-Prot: P80723]

 

X

27

Cadherin-1

CDH1

[Swiss-Prot: P12830]

 

X

28

Calmodulin-like protein 3

CALML3

[Swiss-Prot: P27482]

√

 

29

Calpain-1 catalytic subunit

CAPN1

[Swiss-Prot: P07384]

 

X

30

Catalase

CAT

[Swiss-Prot: P04040]

√

 

31

Cathepsin B

CTSB

[Swiss-Prot: P07858]

√

 

32

Cathepsin D

CTSD

[Swiss-Prot: P07339]

 

X

33

Cathepsin G

CTSG

[Swiss-Prot: P08311]

√

 

34

CD44 antigen

CD44

[Swiss-Prot: P16070]

  

35

Ceruloplasmin

CP

[Swiss-Prot: P00450]

√

 

36

Chitotriosidase-1

CHIT1

[Swiss-Prot: Q13231]

 

X

37

Complement C3

C3

[Swiss-Prot: P01024]

√

 

38

Complement C4-A

C4A

[Swiss-Prot: P0C0L4]

 

X

39

Complement component C8 gamma chain

C8G

[Swiss-Prot: P07360]

  

40

Complement decay-accelerating factor

CD55

[Swiss-Prot: P08174]

 

X

41

Complement factor H

CFH

[Swiss-Prot: P08603]

√

 

42

Cystatin-B

CSTB

[Swiss-Prot: P04080]

√

 

43

Cytochrome c

CYCS

[Swiss-Prot: P99999]

 

X

44

Dipeptidyl peptidase 4

DPP4

[Swiss-Prot: P27487]

 

X

45

Elongation factor 1-alpha 1

EEF1A1

[Swiss-Prot: P68104]

√

 

46

Elongation factor 1-gamma

EEF1G

[Swiss-Prot: P26641]

 

X

47

Epididymal secretory protein E1

NPC2

[Swiss-Prot: P61916]

 

X

48

Erythrocyte band 7 integral membrane protein

STOM

[Swiss-Prot: P27105]

 

X

49

Ezrin

EZR

[Swiss-Prot: P15311]

 

X

50

Ferritin heavy chain

FTH1

[Swiss-Prot: P02794]

  

51

Ferritin light chain

FTL

[Swiss-Prot: P02792]

 

X

52

Fibrinogen beta chain

FGB

[Swiss-Prot: P02675]

√

 

53

Fibrinogen gamma chain

FGG

[Swiss-Prot: P02679]

√

 

54

Fibronectin

FN1

[Swiss-Prot: P02751]

 

X

55

Fructose-bisphosphate aldolase A

ALDOA

[Swiss-Prot: P04075]

√

 

56

Galectin-3-binding protein

LGALS3BP

[Swiss-Prot: Q08380]

 

X

57

Gamma-glutamylcyclotransferase

GGCT

[Swiss-Prot: O75223]

√

 

58

Gelsolin

GSN

[Swiss-Prot: P06396]

 

X

59

Glutamine synthetase

GLUL

[Swiss-Prot: P15104]

 

X

60

Glutathione reductase, mitochondrial

GSR

[Swiss-Prot: P00390]

 

X

61

Glutathione synthetase

GSS

[Swiss-Prot: P48637]

  

62

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

[Swiss-Prot: P04406]

√

 

63

Haptoglobin

HP

[Swiss-Prot: P00738]

√

 

64

Heat shock cognate 71 kDa protein

HSPA8

[Swiss-Prot: P11142]

√

 

65

Heat shock protein beta-1

HSPB1

[Swiss-Prot: P04792]

√

 

66

Heme-binding protein 2

HEBP2

[Swiss-Prot: Q9Y5Z4]

  

67

Hemoglobin subunit alpha

HBA1

[Swiss-Prot: P69905]

√

 

68

Hemoglobin subunit beta

HBB

[Swiss-Prot: P68871]

√

 

69

Hemopexin

HPX

[Swiss-Prot: P02790]

√

 

70

Histidine-rich glycoprotein

HRG

[Swiss-Prot: P04196]

 

X

71

Histone H4

HIST1H4A

[Swiss-Prot: P62805]

√

 

72

Ig alpha-1 chain C region

IGHA1

[Swiss-Prot: P01876]

√

 

73

Ig gamma-1 chain C region

IGHG1

[Swiss-Prot: P01857]

√

 

74

Ig gamma-3 chain C region

IGHG3

[Swiss-Prot: P01860]

 

X

75

Ig lambda-2 chain C regions

IGLC2

[Swiss-Prot: P0CG05]

  

76

Ig lambda-7 chain C region

IGLC7

[Swiss-Prot: A0M8Q6]

  

77

Ig mu chain C region

IGHM

[Swiss-Prot: P01871]

√

 

78

IgGFc-binding protein

FCGBP

[Swiss-Prot: Q9Y6R7]

  

79

Immunoglobulin J chain

IGJ

[Swiss-Prot: P01591]

√

 

80

Involucrin

IVL

[Swiss-Prot: P07476]

√

 

81

Keratin, type I cytoskeletal 10

KRT10

[Swiss-Prot: P13645]

  

82

Keratin, type I cytoskeletal 13

KRT13

[Swiss-Prot: P13646]

  

83

Keratin, type I cytoskeletal 14

KRT14

[Swiss-Prot: P02533]

  

84

Keratin, type I cytoskeletal 19

KRT19

[Swiss-Prot: P08727]

  

85

Keratin, type II cytoskeletal 1

KRT1

[Swiss-Prot: P04264]

  

86

Keratin, type II cytoskeletal 2

KRT2

[Swiss-Prot : P35908]

  

87

Keratin, type II cytoskeletal 4

KRT4

[Swiss-Prot: P19013]

  

88

Keratin, type II cytoskeletal 5

KRT5

[Swiss-Prot: P13647]

  

89

Keratin, type II cytoskeletal 6A

KRT6A

[Swiss-Prot: P02538]

  

90

Kininogen-1

KNG1

[Swiss-Prot: P01042]

 

X

91

Lactotransferrin

LTF

[Swiss-Prot: P02788]

√

 

92

Lamin-A/C

LMNA

[Swiss-Prot: P02545]

√

 

93

Leucine-rich alpha-2-glycoprotein

LRG1

[Swiss-Prot: P02750]

 

X

94

Leukocyte elastase inhibitor

SERPINB1

[Swiss-Prot: P30740]

√

 

95

Long palate, lung and nasal epithelium carcinoma-associated protein 1

LPLUNC1

[Swiss-Prot: Q8TDL5]

 

X

96

Ly6/PLAUR domain-containing protein 3

LYPD3

[Swiss-Prot: O95274]

 

X

97

Macrophage-capping protein

CAPG

[Swiss-Prot: P40121]

 

X

98

Moesin

MSN

[Swiss-Prot: P26038]

√

 

99

Mucin-16

MUC16

[Swiss-Prot: Q8WXI7]

 

X

100

Mucin-5 AC

MUC5AC

[Swiss-Prot: P98088]

 

X

101

Mucin-5B

MUC5B

[Swiss-Prot: Q9HC84]

√

 

102

Myeloperoxidase

MPO

[Swiss-Prot: P05164]

√

 

103

Myosin-9

MYH9

[Swiss-Prot: P35579]

√

 

104

Neuroblast differentiation-associated protein AHNAK

AHNAK

[Swiss-Prot: Q09666]

√

 

105

Neutrophil gelatinase-associated lipocalin

LCN2

[Swiss-Prot: P80188]

√

 

106

NSFL1 cofactor p47

NSFL1C

[Swiss-Prot: Q9UNZ2]

 

X

107

Peptidyl-prolyl cis-trans isomerase B

PPIB

[Swiss-Prot: P23284]

 

X

108

Periplakin

PPL

[Swiss-Prot: O60437]

√

 

109

Peroxiredoxin-1

PRDX1

[Swiss-Prot: Q06830]

√

 

110

Peroxiredoxin-2

PRDX2

[Swiss-Prot: P32119]

 

X

111

Peroxiredoxin-5, mitochondrial

PRDX5

[Swiss-Prot: P30044]

 

X

112

Peroxiredoxin-6

PRDX6

[Swiss-Prot: P30041]

 

X

113

Phosphoglycerate mutase 1

PGAM1

[Swiss-Prot: P18669]

√

 

114

Plasma protease C1 inhibitor

SERPING1

[Swiss-Prot: P05155]

 

X

115

Plasminogen

PLG

[Swiss-Prot: P00747]

 

X

116

Plastin-2

LCP1

[Swiss-Prot: P13796]

√

 

117

Polymeric immunoglobulin receptor

PIGR

[Swiss-Prot: P01833]

√

 

118

Profilin-1

PFN1

[Swiss-Prot: P07737]

√

 

119

Proteasome subunit alpha type-1

PSMA1

[Swiss-Prot: P25786]

  

120

Proteasome subunit alpha type-3

PSMA3

[Swiss-Prot: P25788]

  

121

Proteasome subunit alpha type-4

PSMA4

[Swiss-Prot: P25789]

 

X

122

Proteasome subunit alpha type-5

PSMA5

[Swiss-Prot: P28066]

 

X

123

Proteasome subunit alpha type-6

PSMA6

[Swiss-Prot: P60900]

 

X

124

Proteasome subunit beta type-1

PSMB1

[Swiss-Prot: P20618]

  

125

Proteasome subunit beta type-4

PSMB4

[Swiss-Prot: P28070]

  

126

Proteasome subunit beta type-6

PSMB6

[Swiss-Prot: P28072]

  

127

Proteasome subunit beta type-8

PSMB8

[Swiss-Prot: P28062]

  

128

Protein disulfide-isomerase

P4HB

[Swiss-Prot: P07237]

√

 

129

Protein disulfide-isomerase A3

PDIA3

[Swiss-Prot: P30101]

 

X

130

Protein disulfide-isomerase A4

PDIA4

[Swiss-Prot: P13667]

 

X

131

Protein disulfide-isomerase A6

PDIA6

[Swiss-Prot: Q15084]

 

X

132

Protein DJ-1

PARK7

[Swiss-Prot: Q99497]

  

133

Protein S100-A8

S100A8

[Swiss-Prot: P05109]

√

 

134

Protein S100-A9

S100A9

[Swiss-Prot: P06702]

√

 

135

Pyruvate kinase isozymes M1/M2

PKM2

[Swiss-Prot: P14618]

√

 

136

Ras GTPase-activating-like protein IQGAP1

IQGAP1

[Swiss-Prot: P46940]

 

X

137

Selenium-binding protein 1

SELENBP1

[Swiss-Prot: Q13228]

  

138

Serotransferrin

TF

[Swiss-Prot: P02787]

√

 

139

Serpin B6

SERPINB6

[Swiss-Prot: P35237]

 

X

140

Serum albumin

ALB

[Swiss-Prot: P02768]

√

 

141

Sulfhydryl oxidase 1

QSOX1

[Swiss-Prot: O00391]

 

X

142

Superoxide dismutase [Cu-Zn]

SOD1

[Swiss-Prot: P00441]

√

 

143

Synaptic vesicle membrane protein VAT-1

VAT1

[Swiss-Prot: Q99536]

 

X

144

Thioredoxin

TXN

[Swiss-Prot: P10599]

√

 

145

Transaldolase

TALDO1

[Swiss-Prot: P37837]

√

 

146

Transitional endoplasmic reticulum ATPase

VCP

[Swiss-Prot: P55072]

 

X

147

Transketolase

TKT

[Swiss-Prot: P29401]

 

X

148

Triosephosphate isomerase

TPI1

[Swiss-Prot: P60174]

√

 

149

Vimentin

VIM

[Swiss-Prot: P08670]

√

 

150

Vinculin

VCL

[Swiss-Prot: P18206]

√

 

151

Vitamin D-binding protein

GC

[Swiss-Prot: P02774]

√

 

152

Vitronectin

VTN

[Swiss-Prot: P04004]

 

X

153

Zinc-alpha-2-glycoprotein

AZGP1

[Swiss-Prot: P25311]

 

X

  1. *Present in the 136 Cervical-Vaginal Fluid Core proteins defined by Zegels et al. [13].
  2. **Proteins that were not identified in the 136 Cervical-Vaginal Fluid Core proteins defined by Zegels et al. [13] but were present in at least one of ten previous studies reviewed by Zegels et al. [10]
Back to article page

Clinical Proteomics

ISSN: 1559-0275