Figure 1

SRM assays with proteins previously found regulated in MSCs from osteoarthritic patients. For the measurements which produced significant differences (p < 0.05) between patients () and controls () the extracted ion chromatogram (XIC) is shown together with maximum, minimum and average ± SD values obtained by measuring peak areas corresponding to the transitions detailed in Table 1(a-i). Two transitions from pyruvate kinase peptides (GDLGIEIPAEK: 571.3(+2)/686.4(y6); IYVDDGLISLQVK: 731.9(+2)/574.4(y5)) were used to normalize the data. ct, controls; MSCs, mesenchymal stem cells; oa, osteoarthritis; SD, standard deviation.