Table 1 A partial list of upregulated regulated proteins in toxoplasma encephalitis

1

HLAB

Major histocompatibility complex, class I, B

It is a membrane protein and a member of HLA complex. It plays an important role in immune system by presenting antigens derived from endoplasmic reticulum.

4.4

2

MPO

Myeloperoxidase

It is a heme protein, expressed mainly in azurophilic granules of neutrophils. It produces hypohalous acid involved in killing of bacteria and pathogens.

3.8

3

SERPINA1

Alpha-1 antitrypsin

It is a member of serpin family. It acts as anti-trypsin inhibitor and its targets mainly include protein like elastase and chymotrysin

2.9

4

CRP

C-reactive protein

It belongs to pentraxin family. It is involved in a wide range of host related immune response reactions.

2.3

5

ICAM-1

Intercellular adhesion molecule 1

It is a glycoprotein, which acts as an intercellular adhesion molecule and is involved in pro-inflammatory pathways.

2.1

6

GRIA3

Glutamate receptor 3 isoform 1

It is a neurotransmitter receptor, which regulates neurophysiological process by acting as an excitatory neurotransmitter.

2.0

7

CACNG2

Voltage-dependent calcium channel gamma-2 subunit

It is an integral membrane protein, which mediates trafficking of AMPA receptor.

1.7

8

SYT1

Synaptotagmin-1

It is an integral membrane protein. It is involved in sensing of Ca2(+) during the process of vesicular trafficking and exocytosis.

1.8

9

STXBP1

Syntaxin-binding protein 1

It plays a significant role in neurotransmission and modulation of synaptic vesicle trafficking.

1.6

10

SYN1

Synapsin-1

It is a phosphoprotein involved in the inhibition of neurotransmission and regulation of synaptogenesis.

1.6