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Figure 2 | Clinical Proteomics

Figure 2

From: Proteogenomic analysis of pathogenic yeast Cryptococcus neoformans using high resolution mass spectrometry

Figure 2

Schematic workflow of proteogenomic analysis. Mass spectrometry derived data was searched against protein database and six-frame translated genome database of C. neoformans var. grubii. Peptides mapping to the protein database confirmed annotated proteins and annotated splice junctions. C represents the number of peptides identified mapping to exons excluding A and B. Peptides unique to six-frame translated genome database were categorized based on their mapping to intergenic regions and regions within the annotated genes. These peptides were used to refine the annotation of genome.

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