Table 1 Tukey-honest significant differences post-hoc test for Proseek data [Stage specific (A-D)] and healthy unaffected control (group E)
Candidate Biomarker | Comparison | Up/Down of expression | Adjusted p-value | Previous studies referring CRC associations |
|---|---|---|---|---|
CEA | D/A | ↑ | 0 | |
D/E | ↑ | 1.70E-12 | ||
D/B | ↑ | 4.13E-12 | ||
D/C | ↑ | 0.0001 | ||
C/A | ↑ | 0.0076 | ||
C/E | ↑ | 0.0304 | ||
IL-8 | D/E | ↑ | 1.23E-06 | |
D/A | ↑ | 2.96E-05 | ||
Prolactin | C/D | ↑ | 1.24E-05 | |
C/E | ↑ | 2.89E-05 | ||
Amphiregulin | D/A | ↑ | 8.95E-07 | [54] |
D/C | ↑ | 1.46E-06 | ||
PDGF-BB | D/A | ↑ | 3.02E-05 | |
IL-6 | B/A | ↑ | 0.0024 | |
B/E | ↑ | 0.0124 | ||
CXCL11 | D/C | ↑ | 0.0155 | [57] |
D/A | ↑ | 0.0387 | ||
CXCL5 | D/A | ↑ | 0.0424 |