Figure 5

Comparison (based on least squared normalization) of Down and non-aneuploid pregnancies at 15–17 weeks gestation: A - shows overlaid average mass spectra with bin median as solid shapes and 5 and 95th centiles as whiskers for Down (black squares) and non-aneuploid (red circles) pregnancies at 6000 to 14,000 m/z. The arrow indicates areas of maximal separation. B - a dot plot of the application of a prediction algorithm score called a Down Predictive Score = Σ y(mz11300 to mz11900) based on the spectral differences of the 10 Down syndrome and 44 non-aneuploid samples indicating potential 70% detection for a 0% false positive rate.