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Fig. 3 | Clinical Proteomics

Fig. 3

From: Histone post-translational modifications in frontal cortex from human donors with Alzheimer’s disease

Fig. 3

Location of core PTMs on nucleosome surface. H2A (blue), H2B (pink), H3 (yellow), and H4 (green) form an octamer in the nucleosome core, which is wrapped by DNA. Nucleosome crystal structure PDB ID: 2CV5 [25] was modified using PyMOL Molecular Graphics System (Version 1.7.2, Schrödinger, LLC). a Methylation sites R55 on H4 and K108 on H3 and ubiquitination site K121 on H2B are shown in red. b Hydrogen bond network of H4 R55. c Hydrogen bond network of H2B K108

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Clinical Proteomics

ISSN: 1559-0275