Fig. 5

Curcumin regulated signaling networks. a Pathway analysis of proteins differentially phosphorylated upon curcumin treatment indicated enrichment of focal adhesion pathway. Proteins identified in this study regulated by curcumin are represented in red (hyperphosphorylated) or green (hypophosphorylated). b Ingenuity network analysis of phosphoproteins regulated by curcumin reveals enrichment of NF-kB sub-network. Solid lines represent protein–protein interactions, dashed lines with an arrow represent enzymatic reactions and solid lines with an arrow represent both protein-protein interactions and enzymatic reactions