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Table 1 The top five biological networks identified by IPA

From: Phosphotyrosine profiling of curcumin-induced signaling

Top functions (Networks) Associated molecules Score Focus molecule
Cellular movement, cell morphology, cellular function and maintenance Catenin, BAG3, BCAR1, BCR, c-Src, CAV1, CRK, CTNND1, DOCK1, EPHA2, F Actin, FAK,GAB1, Igm, LASP1, MLLT4, MYO1E, NFkB, p85, PDLIM1, PEAK1, PI3K p85, PLC gamma, PLCG1, PPP1CA, PPP1CB, PTPN6, PTPN11, Ras, Rock, SHC1, SLC9A1, TJP1, TJP2, TNK2 37 23
Cellular movement, cancer, cellular development ADAM9, ANXA2, Ap1, AXL, BCAR3, calpain, CDH1, COL17A1, CTTN, EGFR, EPS15, ERBB2, ERK1/2, FAM120A, G protein alphi, INPPL1, IQGAP1, ITGB4, JAK2, Mapk, Mek, Mmp, PIK3R1, PTK2, PTPRE, PTPRK, Rac, Rap1, RIN1, SCAMP3, SDCBP, Shc, SRC,Vegf 35 22
Cardiac arrythmia, cardiovascular disease, organismal injury and abnormalities ARHGAP35, Cg, CLDN1, DSG2, DSP, ERK, ER, FLNB, FSH, FUBP3, Growth harmone, HDAC, HNRNPA1, HNRNPA2B1, HNRNPK, Hsp70, Hsp90, HSP90AA1, JNK, JUP, LDLR, LH, PCBP2, PCDH7, PKP2, PLIN3, Ras homologue, RASAL2, RNA polymerase II, Secretase gamma, SPTAN1, TNS3, TUBA1A, TUBA1C 33 21
Cellular assembly and organization, cellular function and maintenance, cell-to-cell signaling and interaction ABLIM1, Akt, ANXA1, CCDC88A, CD3, CFL1, CRKL, ERRFI1, Fibrinogen, G protein beta gamma, Gsk3, Hsp27, IgG, LDL, MAP2K1/2, MAPK1, MAPK3, MAPK13, MAPK14, NEDD9, P38 MAPK, PAG1, PDGF BB, PI3 K (complex), PI3 K (family), pkc, PP2A, PRKCD, PTK2B, SHANK2, STAT5a/b, SYK, TCR, VAV2, YES1 26 18
Embryonic development, hair and skin development and function, organ development AHNAK, AIM1, CASP14, COL7A1, CTNNB1, EPHA1, EPHB2, ERBB2, ERBB2IP, ETV5, FOXQ1, GCHFR, GRB2, HENMT1, HNRNPA3, KRT5, KRT7, KRT14, KRT16, KRT80, NRCAM, OCIAD2, PABPC4, PHLDB1, PKP3, PKP4, QPCT, RPS17, SCG5, SCGB2A2, SHB, SMARCA4, STAT5A, TSPAN13, ZNF185 17 13