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Table 1 The top five biological networks identified by IPA

From: Phosphotyrosine profiling of curcumin-induced signaling

Top functions (Networks)

Associated molecules

Score

Focus molecule

Cellular movement, cell morphology, cellular function and maintenance

Catenin, BAG3, BCAR1, BCR, c-Src, CAV1, CRK, CTNND1, DOCK1, EPHA2, F Actin, FAK,GAB1, Igm, LASP1, MLLT4, MYO1E, NFkB, p85, PDLIM1, PEAK1, PI3K p85, PLC gamma, PLCG1, PPP1CA, PPP1CB, PTPN6, PTPN11, Ras, Rock, SHC1, SLC9A1, TJP1, TJP2, TNK2

37

23

Cellular movement, cancer, cellular development

ADAM9, ANXA2, Ap1, AXL, BCAR3, calpain, CDH1, COL17A1, CTTN, EGFR, EPS15, ERBB2, ERK1/2, FAM120A, G protein alphi, INPPL1, IQGAP1, ITGB4, JAK2, Mapk, Mek, Mmp, PIK3R1, PTK2, PTPRE, PTPRK, Rac, Rap1, RIN1, SCAMP3, SDCBP, Shc, SRC,Vegf

35

22

Cardiac arrythmia, cardiovascular disease, organismal injury and abnormalities

ARHGAP35, Cg, CLDN1, DSG2, DSP, ERK, ER, FLNB, FSH, FUBP3, Growth harmone, HDAC, HNRNPA1, HNRNPA2B1, HNRNPK, Hsp70, Hsp90, HSP90AA1, JNK, JUP, LDLR, LH, PCBP2, PCDH7, PKP2, PLIN3, Ras homologue, RASAL2, RNA polymerase II, Secretase gamma, SPTAN1, TNS3, TUBA1A, TUBA1C

33

21

Cellular assembly and organization, cellular function and maintenance, cell-to-cell signaling and interaction

ABLIM1, Akt, ANXA1, CCDC88A, CD3, CFL1, CRKL, ERRFI1, Fibrinogen, G protein beta gamma, Gsk3, Hsp27, IgG, LDL, MAP2K1/2, MAPK1, MAPK3, MAPK13, MAPK14, NEDD9, P38 MAPK, PAG1, PDGF BB, PI3 K (complex), PI3 K (family), pkc, PP2A, PRKCD, PTK2B, SHANK2, STAT5a/b, SYK, TCR, VAV2, YES1

26

18

Embryonic development, hair and skin development and function, organ development

AHNAK, AIM1, CASP14, COL7A1, CTNNB1, EPHA1, EPHB2, ERBB2, ERBB2IP, ETV5, FOXQ1, GCHFR, GRB2, HENMT1, HNRNPA3, KRT5, KRT7, KRT14, KRT16, KRT80, NRCAM, OCIAD2, PABPC4, PHLDB1, PKP3, PKP4, QPCT, RPS17, SCG5, SCGB2A2, SHB, SMARCA4, STAT5A, TSPAN13, ZNF185

17

13