Fig. 9
From: Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease
Diagnostic LC–MS/MS spectrum of Glu-C-derived peptide confirming the identification of hyper-acetylated HMGB1 derived from inflammatory cells present in patient sera during acetaminophen hepatotoxicity. Amino acids, b and y ions and peptide sequences are indicated on each spectrum. Acetylated lysine residues within HMGB1 are represented by K(Ac). Reprinted with permission from [88]