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Fig. 9 | Clinical Proteomics

Fig. 9

From: Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease

Fig. 9

Diagnostic LC–MS/MS spectrum of Glu-C-derived peptide confirming the identification of hyper-acetylated HMGB1 derived from inflammatory cells present in patient sera during acetaminophen hepatotoxicity. Amino acids, b and y ions and peptide sequences are indicated on each spectrum. Acetylated lysine residues within HMGB1 are represented by K(Ac). Reprinted with permission from [88]

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