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Table 2 Top 10% discriminants of adenocarcinoma

From: Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival

Gene ID

Gene name

Control (mean ± SD)a

Tumor (mean ± SD)a

Fold changeb

p valuec

Ratiod

Percent (%)e

Rankf

SPTB

Spectrin, beta, erythrocytic

10.7 ± 9.3

2.82 ± 2.6

0.3

<0.0000

(7/38)

18

1

SLC4A1

Solute carrier family 4 (anion exchanger), member 1 (Diego blood group)

8.75 ± 5.2

3.8 ± 2.7

0.4

<0.0000

(9/38)

24

2

SPTA1

Spectrin, alpha, erythrocytic 1

13.3 ± 12

4.28 ± 3.4

0.3

<0.0000

(8/38)

21

3

ANK1

Ankyrin 1, erythrocytic

6.28 ± 5.7

1.84 ± 1.8

0.3

0.0001

(8/38)

21

4

EPRS

Glutamyl-prolyl-tRNA synthetase

1.24 ± 0.87

3.15 ± 1.7

2.5

<0.0000

(30/38)

79

5

HBG1

Hemoglobin, gamma A

16.9 ± 9.7

7.44 ± 6.2

0.4

<0.0000

(9/38)

24

6

HBG2

Hemoglobin, gamma G

17 ± 9.7

7.43 ± 6.2

0.4

<0.0000

(9/38)

24

7

COPG1

Coatomer protein complex, subunit gamma 1

1.56 ± 1

2.67 ± 1.4

1.7

0.0036

(29/38)

76

8

HYOU1

Hypoxia up-regulated 1

2.12 ± 1.9

4.74 ± 2.3

2.2

<0.0000

(31/38)

82

9

PTRF

Polymerase I and transcript release factor

7.35 ± 2.8

3.81 ± 2.8

0.5

0.0001

(4/38)

11

10

PDIA4

Protein disulfide isomerase family A, member 4

2.69 ± 2.2

6.23 ± 3.4

2.3

0.0003

(31/38)

82

11

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

0.778 ± 0.83

2.05 ± 1.1

2.6

<0.0000

(32/38)

84

12

STOML2

Stomatin (EPB72)-like 2

0.675 ± 0.39

1.38 ± 0.57

2

0.0084

(32/38)

84

13

LRPPRC

Leucine-rich pentatricopeptide repeat containing

1.31 ± 1.4

3.52 ± 2.5

2.7

0.0001

(29/38)

76

14

NANS

N-acetylneuraminic acid synthase

0.61 ± 0.55

1.64 ± 1.1

2.7

0.0002

(31/38)

82

15

HBD

Hemoglobin, delta

47.3 ± 32

21.7 ± 18

0.5

0.0001

(8/38)

21

16

  1. aValues represent covariate adjusted spectral counts
  2. bRatio of means relative to control
  3. cFalse discovery rate adjusted mixed effects model p value
  4. dRatio represents the number of tumor samples which indicated a higher abundance relative to matched control tissue
  5. ePercent (%) represents number of cases were the respective protein was increased in tumor relative to control
  6. fImportance of metabolic change based on O-PLS-DA model loading
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Clinical Proteomics

ISSN: 1559-0275