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Table 2 Top 10% discriminants of adenocarcinoma

From: Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival

Gene ID Gene name Control (mean ± SD)a Tumor (mean ± SD)a Fold changeb p valuec Ratiod Percent (%)e Rankf
SPTB Spectrin, beta, erythrocytic 10.7 ± 9.3 2.82 ± 2.6 0.3 <0.0000 (7/38) 18 1
SLC4A1 Solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 8.75 ± 5.2 3.8 ± 2.7 0.4 <0.0000 (9/38) 24 2
SPTA1 Spectrin, alpha, erythrocytic 1 13.3 ± 12 4.28 ± 3.4 0.3 <0.0000 (8/38) 21 3
ANK1 Ankyrin 1, erythrocytic 6.28 ± 5.7 1.84 ± 1.8 0.3 0.0001 (8/38) 21 4
EPRS Glutamyl-prolyl-tRNA synthetase 1.24 ± 0.87 3.15 ± 1.7 2.5 <0.0000 (30/38) 79 5
HBG1 Hemoglobin, gamma A 16.9 ± 9.7 7.44 ± 6.2 0.4 <0.0000 (9/38) 24 6
HBG2 Hemoglobin, gamma G 17 ± 9.7 7.43 ± 6.2 0.4 <0.0000 (9/38) 24 7
COPG1 Coatomer protein complex, subunit gamma 1 1.56 ± 1 2.67 ± 1.4 1.7 0.0036 (29/38) 76 8
HYOU1 Hypoxia up-regulated 1 2.12 ± 1.9 4.74 ± 2.3 2.2 <0.0000 (31/38) 82 9
PTRF Polymerase I and transcript release factor 7.35 ± 2.8 3.81 ± 2.8 0.5 0.0001 (4/38) 11 10
PDIA4 Protein disulfide isomerase family A, member 4 2.69 ± 2.2 6.23 ± 3.4 2.3 0.0003 (31/38) 82 11
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.778 ± 0.83 2.05 ± 1.1 2.6 <0.0000 (32/38) 84 12
STOML2 Stomatin (EPB72)-like 2 0.675 ± 0.39 1.38 ± 0.57 2 0.0084 (32/38) 84 13
LRPPRC Leucine-rich pentatricopeptide repeat containing 1.31 ± 1.4 3.52 ± 2.5 2.7 0.0001 (29/38) 76 14
NANS N-acetylneuraminic acid synthase 0.61 ± 0.55 1.64 ± 1.1 2.7 0.0002 (31/38) 82 15
HBD Hemoglobin, delta 47.3 ± 32 21.7 ± 18 0.5 0.0001 (8/38) 21 16
  1. aValues represent covariate adjusted spectral counts
  2. bRatio of means relative to control
  3. cFalse discovery rate adjusted mixed effects model p value
  4. dRatio represents the number of tumor samples which indicated a higher abundance relative to matched control tissue
  5. ePercent (%) represents number of cases were the respective protein was increased in tumor relative to control
  6. fImportance of metabolic change based on O-PLS-DA model loading