Table 1 Major amyloid fibril type identified by LCM-MS/MS

Amyloid protein/gene

Immunoglobulin lamda light chain

Immunoglobulin kappa light chain

Immunoglobulin heavy chain

Immunoglobulin lamda light chain

Immunoglobulin kappa light chain

Transthyretin

Transthyretin

Serum amyloid A (SAA)

Number of subtype cases

32

13

5

17

9

25

6

7

Amyloid forming proteins

 Lambda light chain

32

17

1

2

 Kappa light chain

4

13

2

5

9

4

1

 Ig heavy chain

8

5

6

6

4

1

3

 Transthyretin

1

3

3

25

6

 Apolipoprotein A1

2

3

7

3

 Serum amyloid A (SAA)

7

 Fibrinogen alpha chain

2

1

2

1

 Lysozyme

1

1

1

Cases with low levels of 2nd amyloid forming protein

34 %

46 %

40 %

81 %

89 %

20 %

17 %

57 %

Amyloid associated proteins

 ApoE

21

12

2

16

7

19

6

5

 SAP

16

8

13

6

24

6

4

 ApoA4

23

10

1

16

8

22

6

2

 Amyloid signature

63 %

77 %

0 %

100 %

78 %

92 %

100 %

57 %