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Table 1 Major amyloid fibril type identified by LCM-MS/MS

From: Implementation and evaluation of amyloidosis subtyping by laser-capture microdissection and tandem mass spectrometry

Amyloidosis subtype AL-lambda AL-kappa AH Localised lambda Localised kappa ATTRwt ATTRmut AA
Amyloid protein/gene Immunoglobulin lamda light chain Immunoglobulin kappa light chain Immunoglobulin heavy chain Immunoglobulin lamda light chain Immunoglobulin kappa light chain Transthyretin Transthyretin Serum amyloid A (SAA)
Number of subtype cases 32 13 5 17 9 25 6 7
Amyloid forming proteins         
 Lambda light chain 32    17 1 2   
 Kappa light chain 4 13 2 5 9 4   1
 Ig heavy chain 8   5 6 6 4 1 3
 Transthyretin   1   3 3 25 6  
 Apolipoprotein A1 2 3   7 3    
 Serum amyloid A (SAA)         7
 Fibrinogen alpha chain 2 1   2 1    
 Lysozyme 1 1   1     
Cases with low levels of 2nd amyloid forming protein 34 % 46 % 40 % 81 % 89 % 20 % 17 % 57 %
Amyloid associated proteins         
 ApoE 21 12 2 16 7 19 6 5
 SAP 16 8   13 6 24 6 4
 ApoA4 23 10 1 16 8 22 6 2
 Amyloid signature 63 % 77 % 0 % 100 % 78 % 92 % 100 % 57 %
  1. Not shown in the table: 1 case of TGFb, 2 cases of semenogelin, 2 cases of AFib, 2 cases of ALect