Fig. 1From: The impact of growth hormone on proteomic profiles: a review of mouse and adult human studiesGeneral overview of the GH/IGF-I axis. GH is secreted from the anterior pituitary in response to hypothalamic stimulus and has effects on many tissues in the body, including stimulating large amounts of IGF-I secretion by the l and other tissues. Increases in circulating IGF-I negatively impact GH release from the pituitary glandBack to article page