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Table 3 Change in abundance for quantified complement and complement related proteins for progressive versus non-progressive IgAN and for non-progressive IgAN versus control

From: Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy

UniProt accession

N unique peptides

Protein name

Progressive versus non-progressive IgAN

Non-progressive IgAN versus control

Fold change

p value

Fold change

p value

Complement system components

P02746

4

Complement C1q subcomponent subunit B

1.18

0.57

1.47

0.002

P02747

4

Complement C1q subcomponent subunit C

1.54

0.04

1.18

0.53

P00736

2

Complement C1r subcomponent

2.53

0.001

0.97

0.11

P09871

2

Complement C1s subcomponent

1.43

0.02

1.26

0.28

P00751

17

Complement factor B

1.06

0.68

1.01

0.74

P06681

2

Complement C2

1.36

0.13

1.07

0.57

P01024

105

Complement C3

1.46

0.01

1.93

0.0001

P0C0L4

44

Complement C4-A

1.31

0.45

1.25

0.01

P0C0L5

5

Complement C4-B

2.20

0.01

1.01

0.80

P01031

39

Complement C5

1.93

0.01

2.45

0.00002

P13671

16

Complement C6

2.95

0.0003

1.89

0.0005

P10643

14

Complement C7

2.65

0.001

3.76

0.00001

P07357

19

Complement C8 alpha chain

1.97

0.001

2.51

0.0003

P07358

14

Complement C8 beta chain

1.97

0.01

2.20

0.0003

P07360

10

Complement C8 gamma chain

1.72

0.0002

1.28

0.001

P02748

25

Complement C9

1.65

0.03

4.10

0.00004

Complement system regulators

P13987

2

CD59 glycoprotein

1.26

0.14

1.29

0.07

P10909

14

Clusterin

1.68

0.0004

1.39

0.01

P08603

38

Complement factor H

1.34

0.02

1.58

0.0003

Q03591

9

Complement factor H-related protein 1

1.72

0.10

3.96

0.0002

P36980

3

Complement factor H-related protein 2

1.84

0.003

2.79

0.002

Q02985

4

Complement factor H-related protein 3

2.18

0.08

1.54

0.049

Q9BXR6

22

Complement factor H-related protein 5

1.79

0.01

2.67

0.0002

P17927

13

Complement receptor type 1

0.63

0.04

0.62

0.001

Q2VPA4

4

Complement component receptor 1-like protein

0.72

0.07

0.64

0.01

P04003

14

C4b-binding protein alpha chain

1.86

0.01

0.99

0.87

P04004

18

Vitronectin

1.16

0.18

1.75

0.001

P05155

4

Plasma protease C1 inhibitor

1.51

0.26

1.04

0.65

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Clinical Proteomics

ISSN: 1559-0275