Table 4 Linear associations between complement related proteins significantly altered in Table 3 in the comparison progressive versus non-progressive IgAN and clinical variables at time of biopsy
eGFR | Urinary protein | Systolic blood pressure | ||||
|---|---|---|---|---|---|---|
B* | p value | B* | p value | B* | p value | |
Complement system components | ||||||
Complement C1q subcomponent subunit C | − | 0.3 | + | 0.2 | + | 0.5 |
Complement C1r subcomponent | − | 0.003 | + | 0.5 | + | 0.02 |
Complement C1s subcomponent | − | 0.005 | + | 0.7 | + | 0.003 |
Complement C3 | − | 0.3 | − | 0.5 | + | 0.2 |
Complement C4-B | − | 0.2 | + | 0.9 | + | 0.05 |
Complement C5 | − | 0.04 | − | 0.3 | + | 0.02 |
Complement C6 | − | 0.03 | − | 0.3 | + | 0.09 |
Complement C7 | − | 0.06 | − | 0.5 | + | 0.2 |
Complement C8 alpha chain | − | 0.03 | − | 0.4 | + | 0.05 |
Complement C8 beta chain | − | 0.02 | − | 0.2 | + | 0.004 |
Complement C8 gamma chain | − | 0.1 | + | 0.6 | + | 0.4 |
Complement C9 | − | 0.01 | − | 0.24 | + | 0.01 |
Complement system regulators | ||||||
Clusterin | − | 0.02 | − | 0.3 | + | 0.1 |
Complement factor H | − | 0.1 | − | 0.5 | + | 0.02 |
Complement factor H-related protein 1 | − | 0. 4 | − | 0.8 | + | 0.1 |
Complement factor H-related protein 2 | + | 0.9 | − | 0.9 | + | 0.5 |
Complement factor H-related protein 5 | − | 0.3 | − | 0.5 | + | 0.5 |
Complement receptor type 1 | + | 0.07 | + | 0.9 | − | 0.4 |
C4b-binding protein alpha chain | − | 0.06 | − | 0.4 | + | <0.001 |