Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy

Table 5 Glomerular complement protein abundance in IgAN patients according to MEST score; only proteins significant in Table 3 are included

	M1 versus M0		E1 versus E0		S1 versus S0		T1/2 versus T0
	Fold change	p value	Fold change	p value	Fold change	p value	Fold change	p value
Complement system components
Complement C1q subcomponent subunit C	0.9	0.88	1.1	0.57	1.1	0.71	2.7	0.02
Complement C1r subcomponent	0.8	0.81	1.5	0.37	1.6	0.03	2.7	0.02
Complement C1s subcomponent	0.9	0.76	1.7	0.05	1.5	0.04	2.0	0.01
Complement C3	1.5	0.05	1.5	0.06	0.9	0.86	1.5	0.15
Complement C4-B	1.1	0.75	0.8	0.21	1.3	0.65	2.6	0.01
Complement C5	2.5	0.03	2.3	0.02	1.1	0.57	2.3	0.04
Complement component C6	2.1	0.04	1.7	0.07	0.9	0.69	2.7	0.02
Complement component C7	2.2	0.02	2.4	0.03	1.1	0.55	3.3	0.03
Complement component C8 alpha chain	2.3	0.02	2.2	0.05	1.0	0.64	2.4	0.04
Complement component C8 beta chain	2.0	0.06	2.0	0.05	0.9	0.98	1.8	0.07
Complement component C8 gamma chain	1.7	0.002	1.4	0.05	1.2	0.47	1.6	0.01
Complement component C9	2.3	0.06	2.2	0.04	0.9	0.67	1.9	0.07
Complement system regulators
Clusterin	1.8	0.003	1.4	0.14	1.2	0.28	1.9	0.01
Complement factor H	1.4	0.09	1.5	0.07	1.3	0.33	1.7	0.01
Complement factor H-related protein 1	2.3	0.07	2.2	0.16	1.2	0.85	2.4	0.10
Complement factor H-related protein 2	1.7	0.11	1.8	0.07	1.2	0.90	1.5	0.20
Complement factor H-related protein 5	1.6	0.09	1.4	0.04	0.9	0.94	1.6	0.19
Complement receptor type 1	0.5	0.003	0.6	0.10	0.8	0.30	0.4	0.001
C4b-binding protein alpha chain	0.9	0.67	1.2	0.60	1.2	0.16	2.6	0.001

ISSN: 1559-0275