Table 1 Thirty-two proteins with increased expression in the vitreous of idiopathic macular holes compared with controls
From: A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation
Protein name | Gene | neXtProt ID | Function |
|---|---|---|---|
Melanotransferrin | MELTF | P08582 | Iron ion binding |
Brevican core protein | PGCB | Q96GW7 | Hyaluronan binding; ECM component; involved in cell adhesion |
Neurexin-2 | NRXN2 | Q9P2S2 | Neuronal cell surface protein involved in cell recognition and cell adhesion |
Ubiquitin-associated protein 2 | UBAP2 | Q5T6F2 | Cadherin binding involved in cell–cell adhesion |
Spondin-1 | SPON1 | Q9HCB6 | Cell adhesion protein; found in ECM |
Apolipoprotein B-100 | APOB | P04114 | Phospholipid/cholesterol transporter activity |
Metallothionein-1A | MT1A | P04731 | Zinc ion binding; negative regulation of growth |
Retinol-binding protein 3 | RBP3 | P10745 | Serine-type peptidase activity; found in ECM between retina and RPE |
Fibrinogen gamma chain | FGG | P02679 | Together with fibrinogen α and β, polymerizes to form an insoluble fibrin matrix |
Complement factor H | CFH | P08603 | Acts as cofactor in the inactivation of the alternative complement pathway |
Collagen α-2(IX)chain | COL92A | Q14055 | Structural component of the vitreous |
Versican core protein | VCAN | P13611 | Intracellular signaling and connecting cells with ECM; binds hyaluronan |
Amyloid-like protein 2 | APLP2 | Q06481 | Serine-type endopeptidase inhibitor activity |
Inter-α-trypsin inhibitor heavy chain H2 | ITIH2 | P19823 | Involved as binding protein between hyaluronan and other matrix proteins |
Inter-α-trypsin inhibitor heavy chain H4 | ITIH4 | Q14624 | Type II acute phase response protein; serine-type endopeptidase inhibitor activity |
Collagen α-1(II) chain | COL2A1 | P02458 | Extracellular matrix structural constituent conferring tensile strength |
Target of Nesh-SH3 | ABI3BP | Q7Z7G0 | Collagen binding; ECM organization; positive regulator of cell-substrate adhesion |
Complement factor B | CFB | P00751 | Role in alternative complement pathway; cleaved by factor D into Ba and Bb fragments |
Apolipoprotein A-IV | APOA4 | P06727 | Component of chylomicrons, HDL; cholesterol and lipid transport |
Inter-α-trypsin inhibitor heavy chain H1 | ITIH | P19827 | Carrier of hyaluronan or as binding protein between hyaluronan and other matrix proteins |
Haptoglobin | HP | P00738 | Antioxidant activity |
α-2-Macroglobulin | A2 M | P01023 | Inhibits all four classes of proteinases |
Fibrinogen α chain | FGA | P02671 | Polymerizes with fibrinogen β and γ to form an insoluble fibrin matrix |
Calsyntenin-1 | CLSTN1 | O94985 | Interacts with amyloid precursor protein, kinesin-1 |
Apolipoprotein A-I | APOA1 | P02647 | Cholesterol transport |
Serotransferrin | TF | P02787 | Iron binding transport protein |
Complement C3 | C3 | P01024 | Central role in activation of the complement system |
Ceruloplasmin | CP | P00450 | Copper-binding glycoprotein; ferroxidase activity in oxidizing Fe2+ to Fe3+ |
Gelsolin | GSN | P06396 | Role in actin filament capping and polymerization |
Pigment epithelium-derived factor | SERPINF1 | P36955 | Inhibitor of angiogenesis; neurotrophic |
Complement C4-A | C4A | P0C0L4 | Nonenzymatic component of C3 and C5 convertases; essential for propagation of classical complement pathway |
Serum albumin | ALB | P02768 | Main plasma protein; binds water, Ca2+, Na+, K+, zinc, fatty acids, etc. |