Table 3 List of differentially expressed proteins

Up-regulated in naïve patients and down-regulated in treated patients

 P0DJI9

Serum amyloid A-2 protein

–^b

0.8452

–

Acute-phase response

 P0DJI8

Serum amyloid A-1 protein

–

0.6880

–

Acute-phase response

 A0A0G2JPR0

Complement C4-A

–

0.6873

0.4188

Complement activation

 P05109

Protein S100-A8

–

0.4644

–

Inflammatory response

 Q5VY30

Retinol binding protein 4, plasma, isoform CRA_b

0.2306

0.4052

–

Glucose metabolism

 P61769

Beta-2-microglobulin

–

0.3403

–

Antigen processing and presentation

 P02776

Platelet factor 4

–

0.3367

–

Platelet activation

 P07360

Complement component C8 gamma chain

0.1993

0.3285

–

Complement activation

 P69891

Hemoglobin subunit gamma-1

–

0.3034

–

Blood coagulation

 A0A0A0MSV6

Complement C1q subcomponent subunit B

0.0647

0.2777

0.1604

Complement activation

 P02748

Complement component C9

0.1072

0.2378

0.1359

Complement activation

 P02741

C-reactive protein

–

0.2212

–

Acute-phase response/Inflammatory response

 P59665

Neutrophil defensin 1

–

0.1911

–

Innate immune response

 O75636

Ficolin-3

–

0.1800

–

Complement activation

 P01034

Cystatin-C

–

0.1682

–

Neutrophil degranulation/Defense response

 Q06033

Inter-alpha-trypsin inhibitor heavy chain H3

–

0.1485

–

Platelet degranulation

 P60709

Actin, cytoplasmic 1

–

0.1384

–

Platelet aggregation

 A0A0G2JRQ6

Uncharacterized protein

–

0.0850

–

Unkown

 A0A087X232

Complement C1 s subcomponent

–

0.0730

–

Complement activation

 P00736

Complement C1r subcomponent

–

0.0461

–

Complement activation

 Q9H2R5-5

Isoform 5 of Kallikrein-15

–

0.0423

–

Unknown

 P05062

Fructose-bisphosphate aldolase B

–

0.0389

–

Energy metabolism

 Q8NBI6

Xyloside xylosyltransferase 1

–

0.0259

–

O-glycan processing

 P01833

Polymeric immunoglobulin receptor

–

0.0130

–

Neutrophil degranulation

 O43933

Peroxisome biogenesis factor 1

0.0063

0.0118

–

Peroxisome orgnization

 Q8N573-2

Isoform 2 of Oxidation resistance protein 1

–

0.0102

–

Stress response

 P15924

Desmoplakin

–

0.0084

–

Neutrophil degranulation/Adherens junction organization

Down-regulated in naïve patients and up-regulated in treated patients

 C9JB55

Serotransferrin

1.4212

–

2.4371

Iron ion homeostasis/Platelet degranulation

 P05452

Tetranectin

0.1457

–

0.1796

Ossification/Platelet degranulation

 O75636-2

Isoform 2 of Ficolin-3

0.1364

–

0.2109

Complement activation

 P49908

Selenoprotein P

0.0413

–

0.0380

Response to oxidative stress/Platelet degranulation

 Q15848

Adiponectin

0.0390

–

0.0658

Glucose homeostasis