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Table 2 Proteins significantly up-regulated in good responder patients as indicated in the volcano plot

From: Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases

Acc. Nr.

Protein name

Gene name

log2 fold change (t-test difference)

p value

t-test significant

Immune response related proteins

P05164

Myeloperoxidase

MPO

4.53

1.69E − 05

*

P01909

HLA class II histocompatibility antigen, DQ alpha 1 chain

HLA-DQA1

1.43

1.01E − 03

 

P04233

HLA class II histocompatibility antigen gamma chain

CD74

1.74

7.47E − 03

 

P20039

HLA class II histocompatibility antigen, DRB1-11 beta chain

HLA-DRB1

2.99

2.46E − 03

 

Q95365

HLA class I histocompatibility antigen, B-38 alpha chain

HLA-B

1.84

3.64E − 03

 

Q5Y7A7

HLA class II histocompatibility antigen, DRB1-13 beta chain

HLA-DRB1

1.38

1.70E − 03

 

P01594

Ig kappa chain V-I region AU

 

1.07

7.46E − 03

 

P01609

Ig kappa chain V-I region Scw

 

1.58

2.02E − 03

 

P01613

Ig kappa chain V-I region Ni

 

1.86

1.68E − 02

 

P01617

Ig kappa chain V-II region TEW

 

1.61

4.60E − 03

 

P01623

Ig kappa chain V-III region WOL

 

1.89

1.87E − 03

 

P01777

Ig heavy chain V-III region TEI

 

1.78

1.97E − 03

 

P01767

Ig heavy chain V-III region BUT

 

1.46

3.39E − 02

 

P01779

Ig heavy chain V-III region TUR

 

2.24

9.82E − 04

 

P01834

Ig kappa chain C region

IGKC

1.56

4.17E − 03

 

P01857

Ig gamma-1 chain C region

IGHG1

1.40

9.49E − 03

 

P01860

Ig gamma-3 chain C region

IGHG3

1.42

1.01E − 02

 

P01871

Ig mu chain C region

IGHM

2.24

7.25E − 03

 

P01876

Ig alpha-1 chain C region

IGHA1

1.12

5.26E − 02

 

P01880

Ig delta chain C region

IGHD

1.36

4.04E − 02

 

Apolipoproteins

O14791

Apolipoprotein L1

APOL1

1.82

1.43E − 03

 

P02647

Apolipoprotein A-I

APOA1

1.94

2.86E − 04

 

P04114

Apolipoprotein B-100

APOB

3.55

1.17E − 03

 

P06727

Apolipoprotein A-IV

APOA4

5.06

2.61E − 06

*

Cell adhesion (in immune response)

P16284

Platelet endothelial cell adhesion molecule

PECAM1

1.48

5.04E − 02

 

P31997

Carcinoembryonic antigen-related cell adhesion molecule 8

CEACAM8

1.86

3.08E − 03

 

P40199

Carcinoembryonic antigen-related cell adhesion molecule 6

CEACAM6

1.16

3.99E − 02

 

Extracellular matrix (ECM) components

P02452

Collagen alpha-1(I) chain

COL1A1

3.67

2.18E − 02

 

P02751

Fibronectin

FN1

2.61

4.26E − 03

 

P08123

Collagen alpha-2(I) chain

COL1A2

3.24

1.25E − 02

 

P25067

Collagen alpha-2(VIII) chain

COL8A2

1.29

9.84E − 03

 

P39059

Collagen alpha-1(XV) chain

COL15A1

1.48

4.46E − 02

 

Q05707

Collagen alpha-1(XIV) chain

COL14A1

2.53

5.55E − 02

 

Q96P44

Collagen alpha-1(XXI) chain

COL21A1

1.78

3.42E − 02

 
  1. The table shows UniProt accession number (Acc. Nr.), protein name, gene name, t-test difference between LFQ values of poor and good responding patients (fold change, logarithmic scale to the base of two) with corresponding p values and t-test significance (rows with a t-test result above s0 = 0.5 and FDR 0.01 are reported as significant)
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Clinical Proteomics

ISSN: 1559-0275