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Table 2 Detailed statistical analysis of 49 DEPs that were shared in at least two comparison groups

From: Quantitative proteomic analysis of pancreatic cyst fluid proteins associated with malignancy in intraductal papillary mucinous neoplasms

Protein name LGD versus HGD HGD versus invasive IPMN LGD versus invasive IPMN
t test significance p value Fold-change t test significance p value Fold-change t test significance p value Fold-change
EH domain-containing protein 1 + 0.00594 − 15.43 + 0.01955 7.35   0.54376 − 2.10
Immunoglobulin lambda variable 3–21 + 0.00586 − 18.35 + 0.00001 41.24   0.54057 2.25
Collagen alpha-1(VI) chain + 0.00224 − 22.78 + 0.01403 5.61   0.19350 − 4.06
Vacuolar protein sorting-associated protein 37B + 0.01350 − 6.78 + 0.04669 4.56   0.76562 − 1.49
Ig lambda-6 chain C region + 0.03265 − 4.96 + 0.02993 20.47   0.31759 4.13
Ras-related protein Ral-B + 0.00571 − 5.53 + 0.00111 12.71   0.33130 2.30
Lysozyme C + 0.03497 3.95 + 0.03528 − 5.79   0.66323 − 1.47
Immunoglobulin heavy variable 1/OR15-1   0.00000 1.00 + 0.02490 5.06 + 0.00046 7.47
Immunoglobulin lambda variable 5–45   0.93977 − 1.15 + 0.03513 17.43 + 0.02740 15.11
bAldo–keto reductase family 1 member B10   0.97902 − 1.08 + 0.00808 − 131.01 + 0.02709 − 140.91
Ig heavy chain V–III region TIL   0.22132 − 1.77 + 0.00288 6.15 + 0.00022 3.48
Ig heavy chain V–III region BUT   0.61619 1.58 + 0.01276 4.09 + 0.03193 6.47
Ig heavy chain V–III region BUR   0.61583 1.72 + 0.03530 5.43 + 0.03177 9.36
Ig heavy chain V–III region ZAP   0.81620 1.29 + 0.01443 6.03 + 0.00587 7.80
Ig alpha-2 chain C region   0.14392 − 2.13 + 0.02303 3.70 + 0.02778 1.74
aThymidine phosphorylase   0.89045 − 1.25 + 0.00774 48.91 + 0.01333 39.00
aTestis-expressed sequence 12 protein   0.75598 − 1.40 + 0.01204 16.69 + 0.00379 11.94
aProtein Hook homolog 1   0.33603 2.29 + 0.00053 50.05 + 0.00000 114.50
Collagen alpha-1(XV) chain + 0.00001 − 11.37   0.54289 1.75 + 0.01252 − 6.49
Prosaposin + 0.01353 − 2.27   0.69798 1.16 + 0.00131 − 1.95
bPhosphoinositide-3-kinase-interacting protein 1 + 0.00707 − 7.41   0.00000 1.00 + 0.01999 − 7.35
bThy-1 membrane glycoprotein + 0.00966 − 8.39   0.00000 1.00 + 0.01176 − 10.48
Latent-transforming growth factor beta-binding protein 2 + 0.01295 − 30.47   0.83621 1.13 + 0.02886 − 26.88
Protein disulfide-isomerase A3 + 0.00534 27.04   0.64689 − 1.78 + 0.00176 15.23
Agrin + 0.01010 − 95.04   0.64723 1.58 + 0.03007 − 59.97
Alpha-1-antichymotrypsin + 0.00041 − 8.93   0.52129 1.65 + 0.01226 − 5.40
Collagen alpha-1(IV) chain + 0.00000 − 23.08   0.36550 2.54 + 0.01235 − 9.09
bTrefoil factor 1 + 0.03148 − 4.27   0.32370 − 4.75 + 0.03214 − 20.28
bPlasma serine protease inhibitor + 0.00000 − 3.00   0.07044 − 2.33 + 0.00013 − 7.00
Guanine nucleotide-binding protein G(k) subunit alpha + 0.00446 − 7.09   0.57151 1.44 + 0.01032 − 4.92
Guanine nucleotide-binding protein G(k) subunit alpha + 0.00042 − 12.58   0.94988 − 1.07 + 0.00077 − 13.45
Collagen alpha-3(VI) chain + 0.00016 − 41.81   0.61089 2.11 + 0.00316 − 19.85
aTyrosine-protein phosphatase non-receptor type 6 + 0.02363 4.39   0.50095 1.58 + 0.00391 6.95
bKallistatin + 0.01495 − 6.30   0.68656 1.42 + 0.01178 − 4.45
bFibrillin-1 + 0.00000 − 57.02   0.43700 1.93 + 0.00012 − 29.49
bClaudin-18 + 0.00001 − 14.94   0.67515 − 1.49 + 0.00101 − 22.20
Coronin-7 + 0.00858 6.09   0.85877 − 1.18 + 0.01207 5.15
aNuclease-sensitive element-binding protein 1 + 0.04238 6.17   0.62145 1.67 + 0.00138 10.30
Histone H3.1 + 0.00023 10.62   0.25248 − 2.30 + 0.01205 4.62
bMucin-5AC + 0.02741 − 15.38   0.69722 − 1.94 + 0.02010 − 29.87
aMucin-2 + 0.00006 7068.07   0.76813 − 3.54 + 0.03333 1996.84
bWAP four-disulfide core domain protein 2 + 0.00554 − 13.23   0.83040 − 1.38 + 0.00690 − 18.23
bCystatin-M + 0.01152 − 19.49   0.00000 1.00 + 0.03235 − 13.72
BPI fold-containing family B member 1 + 0.00026 − 27.59   0.49944 1.78 + 0.00180 − 15.53
Intelectin-1 + 0.01505 844.39   0.76240 − 3.48 + 0.01605 242.93
aTalin-1 + 0.03653 8.08   0.60098 1.46 + 0.02980 11.78
Basement membrane-specific heparan sulfate proteoglycan core protein + 0.00003 − 114.37 + 0.00582 13.69 + 0.03552 − 8.35
Histone H3 + 0.00007 22.86 + 0.01650 − 3.15 + 0.00843 7.26
Cadherin-related family member 2 + 0.00024 − 52.14 + 0.02477 13.15 + 0.02747 − 3.96
  1. aDominantly expressed in invasive IPMN
  2. bDominantly expressed in LGD
Protein name SignalP SecretomeP TMHMM The Human Protein Atlas Human plasma proteome
Passed Passed Passed RNA expression Protein expression Included
EH domain-containing protein 1 Y Y
Immunoglobulin lambda variable 3–21 Y Y
Collagen alpha-1(VI) chain Y Y Y
Vacuolar protein sorting-associated protein 37B Y Y Y
Ig lambda-6 chain C region Y
Ras-related protein Ral-B Y Y
Lysozyme C Y Y Y Y Y
Immunoglobulin heavy variable 1/OR15-1 Y Y
Immunoglobulin lambda variable 5–45 Y Y
bAldo–keto reductase family 1 member B10
Ig heavy chain V–III region TIL Y
Ig heavy chain V–III region BUT Y
Ig heavy chain V–III region BUR Y
Ig heavy chain V–III region ZAP
Ig alpha-2 chain C region Y Y
aThymidine phosphorylase Y Y Y
aTestis-expressed sequence 12 protein Y Y
aProtein Hook homolog 1 Y Y
Collagen alpha-1(XV) chain Y Y
Prosaposin Y Y Y Y Y
bPhosphoinositide-3-kinase-interacting protein 1 Y Y Y
bThy-1 membrane glycoprotein Y Y Y
Latent-transforming growth factor beta-binding protein 2 Y Y Y
Protein disulfide-isomerase A3 Y Y Y
Agrin Y Y Y
Alpha-1-antichymotrypsin Y Y Y Y Y
Collagen alpha-1(IV) chain Y Y Y
bTrefoil factor 1 Y Y Y Y
bPlasma serine protease inhibitor Y Y Y Y
Guanine nucleotide-binding protein G(k) subunit alpha Y Y Y Y
Guanine nucleotide-binding protein G(k) subunit alpha Y Y Y Y
Collagen alpha-3(VI) chain Y Y Y
aTyrosine-protein phosphatase non-receptor type 6 Y Y
bKallistatin Y Y Y Y Y
bFibrillin-1 Y Y Y
bClaudin-18 Y Y
Coronin-7 Y Y Y
aNuclease-sensitive element-binding protein 1 Y Y Y Y
Histone H3.1 Y Y
bMucin-5AC Y
aMucin-2 Y Y
bWAP four-disulfide core domain protein 2 Y Y Y Y Y
bCystatin-M Y Y Y
BPI fold-containing family B member 1 Y Y Y Y
Intelectin-1 Y Y Y Y
aTalin-1 Y Y Y
Basement membrane-specific heparan sulfate proteoglycan core protein Y Y Y Y
Histone H3 Y Y
Cadherin-related family member 2 Y Y Y Y
  1. aDominantly expressed in invasive IPMN
  2. bDominantly expressed in LGD