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Table 2 Detailed statistical analysis of 49 DEPs that were shared in at least two comparison groups

From: Quantitative proteomic analysis of pancreatic cyst fluid proteins associated with malignancy in intraductal papillary mucinous neoplasms

Protein name

LGD versus HGD

HGD versus invasive IPMN

LGD versus invasive IPMN

t test significance

p value

Fold-change

t test significance

p value

Fold-change

t test significance

p value

Fold-change

EH domain-containing protein 1

+

0.00594

− 15.43

+

0.01955

7.35

 

0.54376

− 2.10

Immunoglobulin lambda variable 3–21

+

0.00586

− 18.35

+

0.00001

41.24

 

0.54057

2.25

Collagen alpha-1(VI) chain

+

0.00224

− 22.78

+

0.01403

5.61

 

0.19350

− 4.06

Vacuolar protein sorting-associated protein 37B

+

0.01350

− 6.78

+

0.04669

4.56

 

0.76562

− 1.49

Ig lambda-6 chain C region

+

0.03265

− 4.96

+

0.02993

20.47

 

0.31759

4.13

Ras-related protein Ral-B

+

0.00571

− 5.53

+

0.00111

12.71

 

0.33130

2.30

Lysozyme C

+

0.03497

3.95

+

0.03528

− 5.79

 

0.66323

− 1.47

Immunoglobulin heavy variable 1/OR15-1

 

0.00000

1.00

+

0.02490

5.06

+

0.00046

7.47

Immunoglobulin lambda variable 5–45

 

0.93977

− 1.15

+

0.03513

17.43

+

0.02740

15.11

bAldo–keto reductase family 1 member B10

 

0.97902

− 1.08

+

0.00808

− 131.01

+

0.02709

− 140.91

Ig heavy chain V–III region TIL

 

0.22132

− 1.77

+

0.00288

6.15

+

0.00022

3.48

Ig heavy chain V–III region BUT

 

0.61619

1.58

+

0.01276

4.09

+

0.03193

6.47

Ig heavy chain V–III region BUR

 

0.61583

1.72

+

0.03530

5.43

+

0.03177

9.36

Ig heavy chain V–III region ZAP

 

0.81620

1.29

+

0.01443

6.03

+

0.00587

7.80

Ig alpha-2 chain C region

 

0.14392

− 2.13

+

0.02303

3.70

+

0.02778

1.74

aThymidine phosphorylase

 

0.89045

− 1.25

+

0.00774

48.91

+

0.01333

39.00

aTestis-expressed sequence 12 protein

 

0.75598

− 1.40

+

0.01204

16.69

+

0.00379

11.94

aProtein Hook homolog 1

 

0.33603

2.29

+

0.00053

50.05

+

0.00000

114.50

Collagen alpha-1(XV) chain

+

0.00001

− 11.37

 

0.54289

1.75

+

0.01252

− 6.49

Prosaposin

+

0.01353

− 2.27

 

0.69798

1.16

+

0.00131

− 1.95

bPhosphoinositide-3-kinase-interacting protein 1

+

0.00707

− 7.41

 

0.00000

1.00

+

0.01999

− 7.35

bThy-1 membrane glycoprotein

+

0.00966

− 8.39

 

0.00000

1.00

+

0.01176

− 10.48

Latent-transforming growth factor beta-binding protein 2

+

0.01295

− 30.47

 

0.83621

1.13

+

0.02886

− 26.88

Protein disulfide-isomerase A3

+

0.00534

27.04

 

0.64689

− 1.78

+

0.00176

15.23

Agrin

+

0.01010

− 95.04

 

0.64723

1.58

+

0.03007

− 59.97

Alpha-1-antichymotrypsin

+

0.00041

− 8.93

 

0.52129

1.65

+

0.01226

− 5.40

Collagen alpha-1(IV) chain

+

0.00000

− 23.08

 

0.36550

2.54

+

0.01235

− 9.09

bTrefoil factor 1

+

0.03148

− 4.27

 

0.32370

− 4.75

+

0.03214

− 20.28

bPlasma serine protease inhibitor

+

0.00000

− 3.00

 

0.07044

− 2.33

+

0.00013

− 7.00

Guanine nucleotide-binding protein G(k) subunit alpha

+

0.00446

− 7.09

 

0.57151

1.44

+

0.01032

− 4.92

Guanine nucleotide-binding protein G(k) subunit alpha

+

0.00042

− 12.58

 

0.94988

− 1.07

+

0.00077

− 13.45

Collagen alpha-3(VI) chain

+

0.00016

− 41.81

 

0.61089

2.11

+

0.00316

− 19.85

aTyrosine-protein phosphatase non-receptor type 6

+

0.02363

4.39

 

0.50095

1.58

+

0.00391

6.95

bKallistatin

+

0.01495

− 6.30

 

0.68656

1.42

+

0.01178

− 4.45

bFibrillin-1

+

0.00000

− 57.02

 

0.43700

1.93

+

0.00012

− 29.49

bClaudin-18

+

0.00001

− 14.94

 

0.67515

− 1.49

+

0.00101

− 22.20

Coronin-7

+

0.00858

6.09

 

0.85877

− 1.18

+

0.01207

5.15

aNuclease-sensitive element-binding protein 1

+

0.04238

6.17

 

0.62145

1.67

+

0.00138

10.30

Histone H3.1

+

0.00023

10.62

 

0.25248

− 2.30

+

0.01205

4.62

bMucin-5AC

+

0.02741

− 15.38

 

0.69722

− 1.94

+

0.02010

− 29.87

aMucin-2

+

0.00006

7068.07

 

0.76813

− 3.54

+

0.03333

1996.84

bWAP four-disulfide core domain protein 2

+

0.00554

− 13.23

 

0.83040

− 1.38

+

0.00690

− 18.23

bCystatin-M

+

0.01152

− 19.49

 

0.00000

1.00

+

0.03235

− 13.72

BPI fold-containing family B member 1

+

0.00026

− 27.59

 

0.49944

1.78

+

0.00180

− 15.53

Intelectin-1

+

0.01505

844.39

 

0.76240

− 3.48

+

0.01605

242.93

aTalin-1

+

0.03653

8.08

 

0.60098

1.46

+

0.02980

11.78

Basement membrane-specific heparan sulfate proteoglycan core protein

+

0.00003

− 114.37

+

0.00582

13.69

+

0.03552

− 8.35

Histone H3

+

0.00007

22.86

+

0.01650

− 3.15

+

0.00843

7.26

Cadherin-related family member 2

+

0.00024

− 52.14

+

0.02477

13.15

+

0.02747

− 3.96

Protein name

SignalP

SecretomeP

TMHMM

The Human Protein Atlas

Human plasma proteome

Passed

Passed

Passed

RNA expression

Protein expression

Included

EH domain-containing protein 1

–

–

–

Y

–

Y

Immunoglobulin lambda variable 3–21

Y

Y

–

–

–

–

Collagen alpha-1(VI) chain

Y

–

–

Y

–

Y

Vacuolar protein sorting-associated protein 37B

–

–

–

Y

Y

Y

Ig lambda-6 chain C region

–

Y

–

–

–

–

Ras-related protein Ral-B

–

–

–

Y

Y

–

Lysozyme C

Y

Y

–

Y

Y

Y

Immunoglobulin heavy variable 1/OR15-1

Y

Y

–

–

–

–

Immunoglobulin lambda variable 5–45

Y

Y

–

–

–

–

bAldo–keto reductase family 1 member B10

–

–

–

–

–

–

Ig heavy chain V–III region TIL

–

Y

–

–

–

–

Ig heavy chain V–III region BUT

–

Y

–

–

–

–

Ig heavy chain V–III region BUR

–

Y

–

–

–

–

Ig heavy chain V–III region ZAP

–

–

–

–

–

–

Ig alpha-2 chain C region

–

Y

–

–

–

Y

aThymidine phosphorylase

–

Y

–

Y

–

Y

aTestis-expressed sequence 12 protein

–

Y

–

–

–

Y

aProtein Hook homolog 1

–

–

–

Y

–

Y

Collagen alpha-1(XV) chain

–

–

–

Y

–

Y

Prosaposin

Y

Y

–

Y

Y

Y

bPhosphoinositide-3-kinase-interacting protein 1

Y

–

–

Y

–

Y

bThy-1 membrane glycoprotein

Y

–

–

Y

–

Y

Latent-transforming growth factor beta-binding protein 2

Y

–

–

Y

–

Y

Protein disulfide-isomerase A3

–

–

–

Y

Y

Y

Agrin

Y

–

–

Y

–

Y

Alpha-1-antichymotrypsin

Y

Y

–

Y

Y

Y

Collagen alpha-1(IV) chain

Y

–

–

Y

–

Y

bTrefoil factor 1

Y

Y

–

Y

–

Y

bPlasma serine protease inhibitor

Y

Y

–

Y

–

Y

Guanine nucleotide-binding protein G(k) subunit alpha

–

Y

–

Y

Y

Y

Guanine nucleotide-binding protein G(k) subunit alpha

Y

–

–

Y

Y

Y

Collagen alpha-3(VI) chain

Y

–

–

Y

–

Y

aTyrosine-protein phosphatase non-receptor type 6

–

–

–

Y

–

Y

bKallistatin

Y

Y

–

Y

Y

Y

bFibrillin-1

Y

–

–

Y

–

Y

bClaudin-18

–

–

Y

Y

–

–

Coronin-7

–

–

–

Y

Y

Y

aNuclease-sensitive element-binding protein 1

–

Y

–

Y

Y

Y

Histone H3.1

–

Y

–

–

Y

–

bMucin-5AC

Y

–

–

–

–

–

aMucin-2

Y

–

–

–

–

Y

bWAP four-disulfide core domain protein 2

Y

Y

Y

Y

–

Y

bCystatin-M

Y

Y

–

–

–

Y

BPI fold-containing family B member 1

Y

Y

Y

–

–

Y

Intelectin-1

Y

Y

–

Y

–

Y

aTalin-1

–

–

–

Y

Y

Y

Basement membrane-specific heparan sulfate proteoglycan core protein

Y

–

–

Y

Y

Y

Histone H3

–

Y

–

–

Y

–

Cadherin-related family member 2

Y

Y

Y

–

–

Y

  1. aDominantly expressed in invasive IPMN
  2. bDominantly expressed in LGD
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Clinical Proteomics

ISSN: 1559-0275