Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Detailed statistical analysis of 49 DEPs that were shared in at least two comparison groups

From: Quantitative proteomic analysis of pancreatic cyst fluid proteins associated with malignancy in intraductal papillary mucinous neoplasms

Protein name LGD versus HGD HGD versus invasive IPMN LGD versus invasive IPMN
t test significance p value Fold-change t test significance p value Fold-change t test significance p value Fold-change
EH domain-containing protein 1 + 0.00594 − 15.43 + 0.01955 7.35   0.54376 − 2.10
Immunoglobulin lambda variable 3–21 + 0.00586 − 18.35 + 0.00001 41.24   0.54057 2.25
Collagen alpha-1(VI) chain + 0.00224 − 22.78 + 0.01403 5.61   0.19350 − 4.06
Vacuolar protein sorting-associated protein 37B + 0.01350 − 6.78 + 0.04669 4.56   0.76562 − 1.49
Ig lambda-6 chain C region + 0.03265 − 4.96 + 0.02993 20.47   0.31759 4.13
Ras-related protein Ral-B + 0.00571 − 5.53 + 0.00111 12.71   0.33130 2.30
Lysozyme C + 0.03497 3.95 + 0.03528 − 5.79   0.66323 − 1.47
Immunoglobulin heavy variable 1/OR15-1   0.00000 1.00 + 0.02490 5.06 + 0.00046 7.47
Immunoglobulin lambda variable 5–45   0.93977 − 1.15 + 0.03513 17.43 + 0.02740 15.11
bAldo–keto reductase family 1 member B10   0.97902 − 1.08 + 0.00808 − 131.01 + 0.02709 − 140.91
Ig heavy chain V–III region TIL   0.22132 − 1.77 + 0.00288 6.15 + 0.00022 3.48
Ig heavy chain V–III region BUT   0.61619 1.58 + 0.01276 4.09 + 0.03193 6.47
Ig heavy chain V–III region BUR   0.61583 1.72 + 0.03530 5.43 + 0.03177 9.36
Ig heavy chain V–III region ZAP   0.81620 1.29 + 0.01443 6.03 + 0.00587 7.80
Ig alpha-2 chain C region   0.14392 − 2.13 + 0.02303 3.70 + 0.02778 1.74
aThymidine phosphorylase   0.89045 − 1.25 + 0.00774 48.91 + 0.01333 39.00
aTestis-expressed sequence 12 protein   0.75598 − 1.40 + 0.01204 16.69 + 0.00379 11.94
aProtein Hook homolog 1   0.33603 2.29 + 0.00053 50.05 + 0.00000 114.50
Collagen alpha-1(XV) chain + 0.00001 − 11.37   0.54289 1.75 + 0.01252 − 6.49
Prosaposin + 0.01353 − 2.27   0.69798 1.16 + 0.00131 − 1.95
bPhosphoinositide-3-kinase-interacting protein 1 + 0.00707 − 7.41   0.00000 1.00 + 0.01999 − 7.35
bThy-1 membrane glycoprotein + 0.00966 − 8.39   0.00000 1.00 + 0.01176 − 10.48
Latent-transforming growth factor beta-binding protein 2 + 0.01295 − 30.47   0.83621 1.13 + 0.02886 − 26.88
Protein disulfide-isomerase A3 + 0.00534 27.04   0.64689 − 1.78 + 0.00176 15.23
Agrin + 0.01010 − 95.04   0.64723 1.58 + 0.03007 − 59.97
Alpha-1-antichymotrypsin + 0.00041 − 8.93   0.52129 1.65 + 0.01226 − 5.40
Collagen alpha-1(IV) chain + 0.00000 − 23.08   0.36550 2.54 + 0.01235 − 9.09
bTrefoil factor 1 + 0.03148 − 4.27   0.32370 − 4.75 + 0.03214 − 20.28
bPlasma serine protease inhibitor + 0.00000 − 3.00   0.07044 − 2.33 + 0.00013 − 7.00
Guanine nucleotide-binding protein G(k) subunit alpha + 0.00446 − 7.09   0.57151 1.44 + 0.01032 − 4.92
Guanine nucleotide-binding protein G(k) subunit alpha + 0.00042 − 12.58   0.94988 − 1.07 + 0.00077 − 13.45
Collagen alpha-3(VI) chain + 0.00016 − 41.81   0.61089 2.11 + 0.00316 − 19.85
aTyrosine-protein phosphatase non-receptor type 6 + 0.02363 4.39   0.50095 1.58 + 0.00391 6.95
bKallistatin + 0.01495 − 6.30   0.68656 1.42 + 0.01178 − 4.45
bFibrillin-1 + 0.00000 − 57.02   0.43700 1.93 + 0.00012 − 29.49
bClaudin-18 + 0.00001 − 14.94   0.67515 − 1.49 + 0.00101 − 22.20
Coronin-7 + 0.00858 6.09   0.85877 − 1.18 + 0.01207 5.15
aNuclease-sensitive element-binding protein 1 + 0.04238 6.17   0.62145 1.67 + 0.00138 10.30
Histone H3.1 + 0.00023 10.62   0.25248 − 2.30 + 0.01205 4.62
bMucin-5AC + 0.02741 − 15.38   0.69722 − 1.94 + 0.02010 − 29.87
aMucin-2 + 0.00006 7068.07   0.76813 − 3.54 + 0.03333 1996.84
bWAP four-disulfide core domain protein 2 + 0.00554 − 13.23   0.83040 − 1.38 + 0.00690 − 18.23
bCystatin-M + 0.01152 − 19.49   0.00000 1.00 + 0.03235 − 13.72
BPI fold-containing family B member 1 + 0.00026 − 27.59   0.49944 1.78 + 0.00180 − 15.53
Intelectin-1 + 0.01505 844.39   0.76240 − 3.48 + 0.01605 242.93
aTalin-1 + 0.03653 8.08   0.60098 1.46 + 0.02980 11.78
Basement membrane-specific heparan sulfate proteoglycan core protein + 0.00003 − 114.37 + 0.00582 13.69 + 0.03552 − 8.35
Histone H3 + 0.00007 22.86 + 0.01650 − 3.15 + 0.00843 7.26
Cadherin-related family member 2 + 0.00024 − 52.14 + 0.02477 13.15 + 0.02747 − 3.96
Protein name SignalP SecretomeP TMHMM The Human Protein Atlas Human plasma proteome
Passed Passed Passed RNA expression Protein expression Included
EH domain-containing protein 1 Y Y
Immunoglobulin lambda variable 3–21 Y Y
Collagen alpha-1(VI) chain Y Y Y
Vacuolar protein sorting-associated protein 37B Y Y Y
Ig lambda-6 chain C region Y
Ras-related protein Ral-B Y Y
Lysozyme C Y Y Y Y Y
Immunoglobulin heavy variable 1/OR15-1 Y Y
Immunoglobulin lambda variable 5–45 Y Y
bAldo–keto reductase family 1 member B10
Ig heavy chain V–III region TIL Y
Ig heavy chain V–III region BUT Y
Ig heavy chain V–III region BUR Y
Ig heavy chain V–III region ZAP
Ig alpha-2 chain C region Y Y
aThymidine phosphorylase Y Y Y
aTestis-expressed sequence 12 protein Y Y
aProtein Hook homolog 1 Y Y
Collagen alpha-1(XV) chain Y Y
Prosaposin Y Y Y Y Y
bPhosphoinositide-3-kinase-interacting protein 1 Y Y Y
bThy-1 membrane glycoprotein Y Y Y
Latent-transforming growth factor beta-binding protein 2 Y Y Y
Protein disulfide-isomerase A3 Y Y Y
Agrin Y Y Y
Alpha-1-antichymotrypsin Y Y Y Y Y
Collagen alpha-1(IV) chain Y Y Y
bTrefoil factor 1 Y Y Y Y
bPlasma serine protease inhibitor Y Y Y Y
Guanine nucleotide-binding protein G(k) subunit alpha Y Y Y Y
Guanine nucleotide-binding protein G(k) subunit alpha Y Y Y Y
Collagen alpha-3(VI) chain Y Y Y
aTyrosine-protein phosphatase non-receptor type 6 Y Y
bKallistatin Y Y Y Y Y
bFibrillin-1 Y Y Y
bClaudin-18 Y Y
Coronin-7 Y Y Y
aNuclease-sensitive element-binding protein 1 Y Y Y Y
Histone H3.1 Y Y
bMucin-5AC Y
aMucin-2 Y Y
bWAP four-disulfide core domain protein 2 Y Y Y Y Y
bCystatin-M Y Y Y
BPI fold-containing family B member 1 Y Y Y Y
Intelectin-1 Y Y Y Y
aTalin-1 Y Y Y
Basement membrane-specific heparan sulfate proteoglycan core protein Y Y Y Y
Histone H3 Y Y
Cadherin-related family member 2 Y Y Y Y
  1. aDominantly expressed in invasive IPMN
  2. bDominantly expressed in LGD