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Fig. 2 | Clinical Proteomics

Fig. 2

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

Fig. 2

Flowchart of the experiment: Nasal lavage sampling before and after exposure to welding fume particles and filtered air. (1) Protein analysis through shotgun proteomics in combination with IPA analysis generates a hypothesis of the mechanisms induced by the welding fume particle exposure. (2) Targeted protein analysis of specific proteins with label-free relative quantification and absolute quantification of MMP9, A1AT, A2MG, APOB, and elastin. (3) Statistical evaluation of the changed protein level with linear mixed model and Wilcoxon signed rank test. (4) Pathway analysis of significantly changed proteins after welding fume particle exposure compared to filtered air exposure

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Clinical Proteomics

ISSN: 1559-0275