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Fig. 4 | Clinical Proteomics

Fig. 4

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

Fig. 4

Network of the significantly changed proteins and the upstream regulators. The significantly changed proteins from the LMM table were associated with the upstream regulators IL6, estrogen receptor, H1FA, IFNG, IL1B, NEUROG1, SPP1, SYVN1, TGFB1, TNF, and STAT3. The canonical pathways connected to these molecular regulators included glucocorticoid receptor signaling. Biomarker enrichment of this network connection showed connections to cystic fibrosis, chronic obstructive pulmonary disease, and asthma. Red = increased measurement, Green = decreased measurement, Orange = indicated activated, Blue = indicated inhibited

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Clinical Proteomics

ISSN: 1559-0275