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Table 2 Significantly changed proteins from the individual samples evaluated with Wilcoxon signed rank test

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

AC Gene name Protein name After exposure Day after exposure Significant peptides FDR
Proteins increased immediately after exposure
P02765 FETUA Alpha-2-HS-glycoprotein Increase   1 f
Proteins increased immediately after exposure and the day after exposure
A6NC86 PINLY Phospholipase A2 inhibitor Increase Increase 1  
P01019 ANGT Angiotensinogen Increase Increase 1 –f
P01834 IGKC Immunoglobulin kappa constant Increase Increase 2  
P01857 IGHG1 Immunoglobulin heavy constant gamma 1 Increase Increase 1  
P02768 ALBU Serum albumin Increase Increase 2  
P26038 MOES Moesin Increase Increase 1  
Q92743 HTRA1 Serine protease HTRA1 Increase Increase 1  
Proteins increased the day after exposure
P01023 A2MG Alpha-2-macroglobulin   Increase 2  
P01859 IGHG2 Immunoglobulin heavy constant gamma 2   Increase 1 f
P02760 AMBP Protein AMBP   Increase 1 f
P02787 TRFE Serotransferrin   Increase 1 f
P02790 HEMO Hemopexin   Increase 1  
P04040 CATA Catalase   Increase 1  
P04792 HSPB1 Heat shock protein beta-1   Increase 1  
P07737 PROF1 Profilin-1   Increase 1 f
P08123 CO1A2 Collagen alpha-2   Increase 1 f
P08603 CFAH Complement factor H   Increase 1  
P15924 DESP Desmoplakin   Increase 1 f
P18510 IL1RA Interleukin-1 receptor antagonist protein   Increase 1 f
P27169 PON1 Serum paraoxonase   Increase 1  
P31947 1433S 14-3-3 protein sigma   Increase 1  
P36955 PEDF Pigment epithelium-derived factor   Increase 1  
Q04118 PRB3 Basic salivary proline-rich protein 3   Increase 1 f
Q07157 ZO1 Tight junction protein ZO-1   Increase 1 f
P11684 UTER Uteroglobin   Increase 2  
Proteins decreased immediately after exposure but increased the day after exposure
P07602 SAP Prosaposin Decrease Increase 2 f,f
Q96IY4 CBPB2 Carboxypeptidase B2 Decrease Increase 2  
P01877 IGHA2 Immunoglobulin heavy constant alpha 2 Decrease Increase 1 f
Proteins decreased immediately after exposure 
O75556 SG2A1 Mammaglobin-B Decrease   1  
P01008 ANT3 Antithrombin-III Decrease   1  
P01034 CYTC Cystatin-C Decrease   2  
P01036 CYTS Cystatin-S Decrease   1  
P04406 G3P Glyceraldehyde-3-phosphate dehydrogenase Decrease   1  
P0DMV9 HS71B Heat shock 70 kDa protein 1B Decrease   1  
P13796 PLSL Plastin-2 Decrease   1  
P14780 MMP9 Matrix metalloproteinase-9 Decrease   1  
P15311 EZRI Ezrin Decrease   1  
P15502 ELN Elastin Decrease   1  
P37802 TAGL2 Transgelin-2 Decrease   1  
Q13822 ENPP2 Ectonucleotide pyrophosphatase Decrease   1  
Q14019 COTL1 Coactosin-like protein Decrease   1  
Q14508 WFDC2 WAP four-disulfide core domain protein 2 Decrease   1  
Q9GZZ8 LACRT Extracellular glycoprotein lacritin Decrease   1  
Q9Y624 JAM1 Junctional adhesion molecule A Decrease   1  
P04080 CYTB Cystatin-B Decrease   1  
Q6UXB2 VCC1 C-X-C motif chemokine 17 Decrease   1  
Q6P5S2 CF058 Protein LEG1 homolog Decrease   2 f,f
Proteins decreased immediately after exposure and the day after exposure
O75594 PGRP1 Peptidoglycan recognition protein 1 Decrease Decrease 2  
P05164 PERM Myeloperoxidase Decrease Decrease 2  
P06727 APOA4 Apolipoprotein A-IV Decrease Decrease 1 f
Proteins decreased the day after exposure
P02749 APOH Beta-2-glycoprotein 1   Decrease 1 f
P02751 FINC Fibronectin   Decrease 1  
P08311 CATG Cathepsin G   Decrease 1  
P20061 TCO1 Transcobalamin-1   Decrease 1 f
Q6UWW0 LCN15 Lipocalin-15   Decrease 1 f
  1. Relative quantification of individual samples generated this list of the significantly changed proteins after welding fume exposure compared to filtered air, and these were statistically evaluated with the Wilcoxon signed rank test both immediately after exposure and the day after exposure, p < 0.05
  2. f Peptides not significantly changed after multiple test correction (FDR), p > 0.036