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Table 2 Significantly changed proteins from the individual samples evaluated with Wilcoxon signed rank test

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

AC

Gene name

Protein name

After exposure

Day after exposure

Significant peptides

FDR

Proteins increased immediately after exposure

P02765

FETUA

Alpha-2-HS-glycoprotein

Increase

 

1

f

Proteins increased immediately after exposure and the day after exposure

A6NC86

PINLY

Phospholipase A2 inhibitor

Increase

Increase

1

 

P01019

ANGT

Angiotensinogen

Increase

Increase

1

–f

P01834

IGKC

Immunoglobulin kappa constant

Increase

Increase

2

 

P01857

IGHG1

Immunoglobulin heavy constant gamma 1

Increase

Increase

1

 

P02768

ALBU

Serum albumin

Increase

Increase

2

 

P26038

MOES

Moesin

Increase

Increase

1

 

Q92743

HTRA1

Serine protease HTRA1

Increase

Increase

1

 

Proteins increased the day after exposure

P01023

A2MG

Alpha-2-macroglobulin

 

Increase

2

 

P01859

IGHG2

Immunoglobulin heavy constant gamma 2

 

Increase

1

f

P02760

AMBP

Protein AMBP

 

Increase

1

f

P02787

TRFE

Serotransferrin

 

Increase

1

f

P02790

HEMO

Hemopexin

 

Increase

1

 

P04040

CATA

Catalase

 

Increase

1

 

P04792

HSPB1

Heat shock protein beta-1

 

Increase

1

 

P07737

PROF1

Profilin-1

 

Increase

1

f

P08123

CO1A2

Collagen alpha-2

 

Increase

1

f

P08603

CFAH

Complement factor H

 

Increase

1

 

P15924

DESP

Desmoplakin

 

Increase

1

f

P18510

IL1RA

Interleukin-1 receptor antagonist protein

 

Increase

1

f

P27169

PON1

Serum paraoxonase

 

Increase

1

 

P31947

1433S

14-3-3 protein sigma

 

Increase

1

 

P36955

PEDF

Pigment epithelium-derived factor

 

Increase

1

 

Q04118

PRB3

Basic salivary proline-rich protein 3

 

Increase

1

f

Q07157

ZO1

Tight junction protein ZO-1

 

Increase

1

f

P11684

UTER

Uteroglobin

 

Increase

2

 

Proteins decreased immediately after exposure but increased the day after exposure

P07602

SAP

Prosaposin

Decrease

Increase

2

f,f

Q96IY4

CBPB2

Carboxypeptidase B2

Decrease

Increase

2

 

P01877

IGHA2

Immunoglobulin heavy constant alpha 2

Decrease

Increase

1

f

Proteins decreased immediately after exposure 

O75556

SG2A1

Mammaglobin-B

Decrease

 

1

 

P01008

ANT3

Antithrombin-III

Decrease

 

1

 

P01034

CYTC

Cystatin-C

Decrease

 

2

 

P01036

CYTS

Cystatin-S

Decrease

 

1

 

P04406

G3P

Glyceraldehyde-3-phosphate dehydrogenase

Decrease

 

1

 

P0DMV9

HS71B

Heat shock 70 kDa protein 1B

Decrease

 

1

 

P13796

PLSL

Plastin-2

Decrease

 

1

 

P14780

MMP9

Matrix metalloproteinase-9

Decrease

 

1

 

P15311

EZRI

Ezrin

Decrease

 

1

 

P15502

ELN

Elastin

Decrease

 

1

 

P37802

TAGL2

Transgelin-2

Decrease

 

1

 

Q13822

ENPP2

Ectonucleotide pyrophosphatase

Decrease

 

1

 

Q14019

COTL1

Coactosin-like protein

Decrease

 

1

 

Q14508

WFDC2

WAP four-disulfide core domain protein 2

Decrease

 

1

 

Q9GZZ8

LACRT

Extracellular glycoprotein lacritin

Decrease

 

1

 

Q9Y624

JAM1

Junctional adhesion molecule A

Decrease

 

1

 

P04080

CYTB

Cystatin-B

Decrease

 

1

 

Q6UXB2

VCC1

C-X-C motif chemokine 17

Decrease

 

1

 

Q6P5S2

CF058

Protein LEG1 homolog

Decrease

 

2

f,f

Proteins decreased immediately after exposure and the day after exposure

O75594

PGRP1

Peptidoglycan recognition protein 1

Decrease

Decrease

2

 

P05164

PERM

Myeloperoxidase

Decrease

Decrease

2

 

P06727

APOA4

Apolipoprotein A-IV

Decrease

Decrease

1

f

Proteins decreased the day after exposure

P02749

APOH

Beta-2-glycoprotein 1

 

Decrease

1

f

P02751

FINC

Fibronectin

 

Decrease

1

 

P08311

CATG

Cathepsin G

 

Decrease

1

 

P20061

TCO1

Transcobalamin-1

 

Decrease

1

f

Q6UWW0

LCN15

Lipocalin-15

 

Decrease

1

f

  1. Relative quantification of individual samples generated this list of the significantly changed proteins after welding fume exposure compared to filtered air, and these were statistically evaluated with the Wilcoxon signed rank test both immediately after exposure and the day after exposure, p < 0.05
  2. f Peptides not significantly changed after multiple test correction (FDR), p > 0.036