Table 2 Proteins found to be significantly enriched in RO
From: Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas
Average log2 (RO/standard) | Average log2 (chRCC/standard) | p-value (limma moderated) | Uniprot ID | Protein names |
|---|---|---|---|---|
1.09 | − 0.57 | 0.00 | P06756 | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
0.35 | − 1.21 | 0.00 | Q9H9J2 | 39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-) (Mitochondrial large ribosomal subunit protein mL44) |
0.46 | − 0.87 | 0.00 | O15382 | Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18) |
0.38 | − 1.28 | 0.00 | P51398 | 28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) (Mitochondrial small ribosomal subunit protein mS29) |
0.40 | − 1.38 | 0.00 | P16219 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) |
0.42 | − 1.17 | 0.00 | Q6PI48 | Aspartate–tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) |
0.50 | − 0.66 | 0.00 | Q9BYD6 | 39S ribosomal protein L1, mitochondrial (L1 mt) (MRP-L1) (Mitochondrial large ribosomal subunit protein uL1m) |
0.36 | − 1.11 | 0.00 | P30048 | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) |
0.33 | − 0.96 | 0.00 | P50897 | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) |
0.33 | − 0.79 | 0.00 | Q96GK7 | Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-) |
0.04 | − 1.53 | 0.00 | P55084 | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] |
0.40 | − 1.02 | 0.00 | Q96EL3 | 39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53) (Mitochondrial large ribosomal subunit protein mL53) |
0.47 | − 1.06 | 0.00 | Q96PE7 | Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase) |
0.04 | − 1.79 | 0.00 | Q8TCS8 | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3′–5′ RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein) |
0.97 | − 0.93 | 0.00 | Q96P44 | Collagen alpha-1(XXI) chain |
0.33 | − 0.61 | 0.00 | P08559 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) |
0.47 | − 0.83 | 0.00 | Q8N5M1 | ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog) |
0.23 | − 1.01 | 0.00 | Q8N0X4 | Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9) |
0.41 | − 1.00 | 0.00 | Q9HD33 | 39S ribosomal protein L47, mitochondrial (L47mt) (MRP-L47) (Mitochondrial large ribosomal subunit protein uL29 m) (Nasopharyngeal carcinoma metastasis-related protein 1) |
0.47 | − 1.00 | 0.00 | Q16822 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) |
1.01 | − 1.26 | 0.00 | P02792 | Ferritin light chain (Ferritin L subunit) |
0.27 | − 0.77 | 0.00 | Q9UIJ7 | GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1) |
0.46 | − 0.73 | 0.00 | Q9NYK5 | 39S ribosomal protein L39, mitochondrial (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5) (Mitochondrial large ribosomal subunit protein mL39) |
0.37 | − 0.58 | 0.00 | P11177 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) |
0.18 | − 1.13 | 0.00 | Q9UFN0 | Protein NipSnap homolog 3A (NipSnap3A) (Protein NipSnap homolog 4) (NipSnap4) (Target for Salmonella secreted protein C) (TassC) |
0.36 | − 0.89 | 0.00 | P12694 | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) |
0.52 | − 0.75 | 0.01 | Q9Y3B7 | 39S ribosomal protein L11, mitochondrial (L11 mt) (MRP-L11) (Mitochondrial large ribosomal subunit protein uL11m) |
0.33 | − 0.72 | 0.01 | Q8N490 | Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2) |
0.54 | − 1.05 | 0.01 | P52815 | 39S ribosomal protein L12, mitochondrial (L12 mt) (MRP-L12) (5c5-2) (Mitochondrial large ribosomal subunit protein bL12m) |
0.40 | − 0.53 | 0.01 | P26038 | Moesin (Membrane-organizing extension spike protein) |
0.67 | − 0.64 | 0.01 | Q9Y619 | Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) |
0.22 | − 1.21 | 0.01 | P22033 | Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase) |
0.60 | − 0.76 | 0.01 | P20674 | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) |
0.80 | − 0.77 | 0.01 | Q15111 | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) |
0.40 | − 0.40 | 0.01 | P27348 | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) |
0.29 | − 0.76 | 0.01 | Q5TEU4 | Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-) |
0.01 | − 1.47 | 0.01 | P10809 | 60 kDa heat shock protein, mitochondrial (EC 3.6.4.9) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) |
0.62 | − 1.18 | 0.01 | Q96CU9 | FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) |
0.46 | − 1.01 | 0.01 | P10606 | Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) |
0.33 | − 0.77 | 0.01 | P04179 | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) |
1.09 | − 0.85 | 0.01 | O14773 | Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) |
0.34 | − 0.63 | 0.01 | P21953 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) |
0.25 | − 0.85 | 0.01 | P03928 | ATP synthase protein 8 (A6L) (F-ATPase subunit 8) |
0.18 | − 1.17 | 0.01 | P30042 | ES1 protein homolog, mitochondrial (Protein GT335) (Protein KNP-I) |
0.44 | − 0.90 | 0.01 | P09001 | 39S ribosomal protein L3, mitochondrial (L3 mt) (MRP-L3) (Mitochondrial large ribosomal subunit protein uL3m) |
0.80 | − 0.55 | 0.01 | Q15067 | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) |
0.37 | − 1.01 | 0.01 | O75947 | ATP synthase subunit d, mitochondrial (ATPase subunit d) |
0.29 | − 0.97 | 0.01 | P82933 | 28S ribosomal protein S9, mitochondrial (MRP-S9) (S9 mt) (Mitochondrial small ribosomal subunit protein uS9m) |
0.38 | − 1.11 | 0.01 | P09669 | Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) |
0.38 | − 1.11 | 0.01 | Q3ZCW2 | Galectin-related protein (Lectin galactoside-binding-like protein) |
0.37 | − 0.90 | 0.01 | Q9Y3D9 | 28S ribosomal protein S23, mitochondrial (MRP-S23) (S23mt) (Mitochondrial small ribosomal subunit protein mS23) |
1.09 | − 0.57 | 0.00 | P06756 | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
0.35 | − 1.21 | 0.00 | Q9H9J2 | 39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-) (Mitochondrial large ribosomal subunit protein mL44) |
0.46 | − 0.87 | 0.00 | O15382 | Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18) |
0.38 | − 1.28 | 0.00 | P51398 | 28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) (Mitochondrial small ribosomal subunit protein mS29) |
0.40 | − 1.38 | 0.00 | P16219 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) |
0.42 | − 1.17 | 0.00 | Q6PI48 | Aspartate–tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) |
0.50 | − 0.66 | 0.00 | Q9BYD6 | 39S ribosomal protein L1, mitochondrial (L1 mt) (MRP-L1) (Mitochondrial large ribosomal subunit protein uL1m) |