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Table 2 p-values for the individual proteins in the discovery and replication steps in the comparison of ovarian cancer to benign tumors, population controls

From: A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer

Uniprot no

Uniprot protein name

Proseek Protein ID

Cancer type

Ovarian cancer versus benign tumors

Ovarian cancer versus populations control

Discovery

Replication

Discovery

Replication

Stage I–IV

Stage I–II

Stage III–IV

Stage I–IV

Stage I–II

Stage III–IV

Versus ovarian cancer stage I–IV

Versus ovarian cancer stage I–II

Versus ovarian cancer stage III–IV

Versus ovarian cancer stage I–IV

Q16651

Prostasin

CVD2_173_PRSS8

OE

1.08E−08

0.437395062

9.05E−11

3.95E−14

0.001859491

4.83E−16

0.028270178

1

1.29E−06

1.91E−05

P21741

Midkine

ONC2_161_MK

OE

2.85E−08

1

2.73E−13

2.60E−08

0.020068076

4.57E−09

0.007863784

1

6.50E−11

1.06E−06

Q14508

Major epididymis-specific protein E4

ONC2_182_WFDC2

OE

4.38E−14

0.012381315

5.28E−17

1.49E−21

7.55E−07

2.68E−23

2.11E−07

1

7.00E−14

2.35E−13

P22301

Interleukin-10

INF_162_IL-10

OE

1.64E−06

1

5.23E−10

0.479046977

1

0.097292101

1

0.00410586

0.529576635

1

P04179

Superoxide dismutase [Mn], mitochondrial

CVD2_137_SOD2

O

0.00066448

1

0.000688683

2.07E−09

0.042029761

8.56E−11

1

1

0.25750062

1.00E−05

P09874

Poly [ADP-ribose] polymerase 1

CVD2_195_PARP-1

O

1.78E−07

1

2.19E−11

3.81E−14

0.00192284

3.50E−16

0.210991816

1

2.04E−07

0.001644308

Q9UBX7

Kallikrein-11

ONC2_121_hK11

O

3.83E−05

1

1.20E−07

3.72E−09

0.001466544

2.15E−09

0.011603143

1

3.43E−06

0.1190456

Q96NY8

Nectin-4

ONC2_141_PVRL4

O

1.50E−06

1

1.57E−09

2.23E−07

0.096598347

2.39E−08

0.258520796

1

1.18E−07

0.242568821

Q8WXI7

Mucin-16

ONC2_191_MUC-16

O

9.15E−23

2.37E−08

4.49E−21

1.20E−16

0.001302092

1.45E−19

6.59E−18

0.752014614

9.16E−25

3.73E−11

P15328

Folate receptor alpha

ONC2_196_FR-alpha

O

3.91E−10

0.115430697

3.90E−12

2.50E−18

0.004482048

3.56E−22

0.000243851

1

5.22E−09

1.14E−05

P22223

Catenin beta-1

NEU_150_CDH3

O

3.91E−05

0.484466735

7.72E−05

1

0.055334855

1

0.118136808

1

0.010350682

1

Q16288

NT-3 growth factor receptor

NEU_190_NTRK3

O

0.030055578

1

0.039744561

2.31E−11

0.003961683

1.35E−12

1

1

1

0.015043749

P10145

Interleukin-8

INF_101_IL-8

O

8.17E−07

1

1.32E−09

9.27E−09

0.027613554

9.11E−10

0.027906542

1

3.41E−06

0.001205718

Q9P0M4

Interleukin-17C

INF_114_IL-17C

O

2.51E−05

0.043046188

0.000689734

1.07E−06

0.000623164

4.22E−06

1

1

1

0.044912595

P80511

Protein S100-A12

INF_175_EN-RAGE

O

4.87E−08

0.000153701

7.40E−05

4.64E−11

4.81E−08

2.15E−09

0.342001882

1

1

0.026901128

  1. NA not applicable