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Table 2 The P-value, area under ROC curve (AUC) and importance in the projection (VIP) of IgG-Fc N-glycans in IgG subclasses for discriminating among AIP patients, PDAC patients, and control

From: High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Glycoform

PDAC versus control

AIP versus control

AIP versus PDAC

P

AUC

VIP

P

AUC

VIP

P

AUC

VIP

Agalactosylation ratio of IgG1

< 0.0001****

0.7542

1.29

0.0776

0.5873

0.66

0.0009***

0.6371

0.48

Agalactosylation ratio of IgG2

0.002**

0.6449

0.95

0.4859

0.5345

0.05

0.0004***

0.6454

0.65

Agalactosylation ratio of IgG4

< 0.0001****

0.7913

1.61

< 0.0001****

0.7729

1.22

0.6415

0.5192

0.05

Agalactosylation ratio of IgG1 and agalactosylation ratio of IgG2

< 0.0001****

0.732

1.28

0.5582

0.529

0.43

0.0001***

0.6581

0.61

Agalactosylation ratio of IgG1 and agalactosylation ratio of IgG4

< 0.0001****

0.8186

1.71

< 0.0001****

0.7258

1.12

0.0618

0.577

0.26

Agalactosylation ratio of IgG2 and agalactosylation ratio of IgG4

< 0.0001****

0.7805

1.58

< 0.0001****

0.6938

1.00

0.0508

0.5806

0.30

Agalactosylation ratio of IgG1, Agalactosylation ratio of IgG2, and Agalactosylation ratio of IgG4

< 0.0001****

0.8041

1.64

0.0009***

0.6636

0.95

0.0094**

0.6072

0.40

Sialylation ratio of IgG1

0.0212*

0.6081

0.48

0.0128*

0.6232

0.65

< 0.0001****

0.6963

0.92

Sialylation ratio of IgG2

0.8262

0.5103

0.00

 < 0.0001****

0.777

1.22

< 0.0001****

0.7625

1.25

Sialylation ratio of IgG4

0.2838

0.5503

0.03

< 0.0001****

0.8641

1.49

< 0.0001****

0.8507

1.46

Sialylation ratio of IgG1 and sialylation ratio of IgG2

0.2666

0.5521

0.32

< 0.0001****

0.7217

1.03

< 0.0001****

0.7483

1.20

Sialylation ratio of IgG1 and sialylation ratio of IgG4

0.0543

0.5902

0.28

< 0.0001****

0.8054

1.32

< 0.0001****

0.8265

1.39

Sialylation ratio of IgG2 and sialylation ratio of IgG4

0.7685

0.5138

0.02

< 0.0001****

0.8676

1.56

< 0.0001****

0.8559

1.57

Sialylation ratio of IgG1, sialylation ratio of IgG2, and sialylation ratio of IgG4

0.3332

0.5454

0.23

< 0.0001****

0.8252

1.39

< 0.0001****

0.8317

1.47

Fucosylation of IgG1

0.0012**

0.6522

1.01

< 0.0001****

0.714

1.00

< 0.0001****

0.8079

1.40

Bisecting GlcNAc of IgG1

0.9494

0.503

0.15

< 0.0001****

0.696

0.99

< 0.0001****

0.7068

0.91

Agalactosylation of IgG1

< 0.0001****

0.7458

1.30

0.3493

0.5463

0.10

< 0.0001****

0.7395

0.95

Sialylation of IgG1

0.1926

0.5611

0.48

0.0241*

0.6116

0.58

< 0.0001****

0.6832

0.87

Galactosylation of IgG1

0.0016**

0.6481

0.80

0.1124

0.5785

0.39

< 0.0001****

0.6931

0.83

  1. Controls (n = 57), PDAC (n = 115), and AIP (n = 86)
  2. P-values: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
  3. Italic values indicate the p-value <  0.0001 and the variables with the highest VIP score and maximum area under ROC curve (AUC) to differentiate AIP from PDAC patients, AIP or PDAC patients from controls
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Clinical Proteomics

ISSN: 1559-0275