From: Discovery of non-invasive biomarkers for the diagnosis of endometriosis
Candidate biomarker | Units | Control (C) | Pain (P) | Endometriosis (E) | E versus C P value | E versus P P value | C versus P P value |
---|---|---|---|---|---|---|---|
(A) | Â | Â | Â | Â | Â | Â | Â |
CA125 | U/mL | 7.7 (1.3–28.0) | 7.7 (0.6–273.0) | 22.5 (0.70–386.6) | 0.0007 | 0.0058 | ns |
oestradiol | pmol/L | 245 (18–2512) | 419 (79–1616) | 345 (18–2110) | ns | ns | ns |
progesterone | nmol/L | 1.9 (0.6–43.7) | 6.1 (0.9–53.4) | 2.3 (0.2–61.7) | ns | ns | ns |
sICAM1 | ng/mL | 301.4 (81.9–502.3) | 265.7 (85.83–624.7) | 342.1 (92.3–730.8) | 0.04 | 0.004 | ns |
IL1R2 | ng/mL | 12.72 (7.65–19.23) | 11.33 (6.41–23.29) | 12.35 (0.57–23.2) | ns | ns | ns |
MCP1 | ng/mL | 0.32 (0.10–1.55) | 0.26 (0.07–1.39) | 0.27 (0.03–2.25) | ns | ns | ns |
MIF | ng/mL | 24.81 (2.20–106.3) | 30.87 (2.22–282.8) | 24.11 (2.25–314.6) | ns | ns | ns |
VEGF | ng/mL | 0.33 (0.07–1.00) | 0.32(0.09–0.95) | 0.41 (0.15–1.41) | ns | ns | ns |
FST | ng/mL | 0.82 (0.27–3.79) | 0.73 (0.28–2.41) | 0.67 (0.23–4.33) | ns | ns | ns |
PAEP | ng/mL | 7.22 (1.03–51.82) | 11.35 (4.92–38.84) | 13.52 (0.70–79.68) | ns | ns | ns |
LUM | ng/mL | 47.05 (0.60–101.1) | 41.7 (0.18–111,3) | 45.0 (6.39–133.0) | ns | ns | ns |
TNC | ng/mL | 40.31 (11.27–152.2) | 73.24 (13.47–154.7) | 46.27 (7.09–182.4) | ns | 0.039 | 0.044 |
CPM | ng/mL | 3.83 (0.4–70.75) | 4.32(0.02–38.03) | 6.13 (0.4–94.62) | ns | ns | ns |
CRP | mg/L | 0.7 (0.6–9.2) | 0.6 (0.6–10.0) | 0.75 (0.6–20.0) | ns | ns | ns |
Candidate biomarker | Secretory phase | Proliferative phase | ||
---|---|---|---|---|
E (n = 26) versus C (n = 9) | E (n = 26) versus P (n = 12) | E (n = 13) versus C (n = 10) | E (n = 13) versus P (n = 9) | |
(B) | Â | Â | Â | Â |
CA125 | 0.006 | 0.003 | ns | ns |
oestrogen | ns | ns | ns | ns |
progesterone | ns | ns | ns | ns |
sICAM1 | ns | 0.026 | ns | ns |
IL1R2 | ns | ns | ns | ns |
MCP1 | ns | ns | ns | ns |
MIF | ns | ns | ns | ns |
VEGF | 0.033 | ns | ns | ns |
FST | ns | ns | 0.011 | ns |
PAEP | ns | ns | ns | ns |
LUM | ns | ns | ns | ns |
TNC | ns | 0.037 | ns | ns |
CPM | ns | ns | ns | ns |
CRP | ns | ns | ns | ns |