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Table 4 (A) Median concentrations and ranges of individual biomarker candidates in serum and P values for comparison of clinical groups in all stages of the menstrual cycle. (B) Analysis by menstrual cycle phase showing significant differences in candidate biomarker levels. P values < 0.05 are considered significant

From: Discovery of non-invasive biomarkers for the diagnosis of endometriosis

Candidate biomarker

Units

Control (C)

Pain (P)

Endometriosis (E)

E versus C P value

E versus P P value

C versus P P value

(A)

       

CA125

U/mL

7.7 (1.3–28.0)

7.7 (0.6–273.0)

22.5 (0.70–386.6)

0.0007

0.0058

ns

oestradiol

pmol/L

245 (18–2512)

419 (79–1616)

345 (18–2110)

ns

ns

ns

progesterone

nmol/L

1.9 (0.6–43.7)

6.1 (0.9–53.4)

2.3 (0.2–61.7)

ns

ns

ns

sICAM1

ng/mL

301.4 (81.9–502.3)

265.7 (85.83–624.7)

342.1 (92.3–730.8)

0.04

0.004

ns

IL1R2

ng/mL

12.72 (7.65–19.23)

11.33 (6.41–23.29)

12.35 (0.57–23.2)

ns

ns

ns

MCP1

ng/mL

0.32 (0.10–1.55)

0.26 (0.07–1.39)

0.27 (0.03–2.25)

ns

ns

ns

MIF

ng/mL

24.81 (2.20–106.3)

30.87 (2.22–282.8)

24.11 (2.25–314.6)

ns

ns

ns

VEGF

ng/mL

0.33 (0.07–1.00)

0.32(0.09–0.95)

0.41 (0.15–1.41)

ns

ns

ns

FST

ng/mL

0.82 (0.27–3.79)

0.73 (0.28–2.41)

0.67 (0.23–4.33)

ns

ns

ns

PAEP

ng/mL

7.22 (1.03–51.82)

11.35 (4.92–38.84)

13.52 (0.70–79.68)

ns

ns

ns

LUM

ng/mL

47.05 (0.60–101.1)

41.7 (0.18–111,3)

45.0 (6.39–133.0)

ns

ns

ns

TNC

ng/mL

40.31 (11.27–152.2)

73.24 (13.47–154.7)

46.27 (7.09–182.4)

ns

0.039

0.044

CPM

ng/mL

3.83 (0.4–70.75)

4.32(0.02–38.03)

6.13 (0.4–94.62)

ns

ns

ns

CRP

mg/L

0.7 (0.6–9.2)

0.6 (0.6–10.0)

0.75 (0.6–20.0)

ns

ns

ns

Candidate biomarker

Secretory phase

Proliferative phase

E (n = 26) versus C (n = 9)

E (n = 26) versus P (n = 12)

E (n = 13) versus C (n = 10)

E (n = 13) versus P (n = 9)

(B)

    

CA125

0.006

0.003

ns

ns

oestrogen

ns

ns

ns

ns

progesterone

ns

ns

ns

ns

sICAM1

ns

0.026

ns

ns

IL1R2

ns

ns

ns

ns

MCP1

ns

ns

ns

ns

MIF

ns

ns

ns

ns

VEGF

0.033

ns

ns

ns

FST

ns

ns

0.011

ns

PAEP

ns

ns

ns

ns

LUM

ns

ns

ns

ns

TNC

ns

0.037

ns

ns

CPM

ns

ns

ns

ns

CRP

ns

ns

ns

ns

  1. C = no pain control; P = pain control; E = endometriosis; ns = not significant