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Table 3 Differences in serum glycopatterns between SCC groups and healthy control by the lectin microarray analysis based on data of 16 lectins giving significant differences

From: Stage-associated differences in the serum N- and O-glycan profiles of patients with non-small cell lung cancer

Lectin Specificity Fold change
I/II SCC/healthy III SCC/healthy IV SCC/healthy
Jacalin Galβ1-3GalNAcα-Ser/Thr(T), sialyl-T(ST) 0.30*** 0.17*** 0.23***
HHL High-Mannose, Manα1-3Man, Manα1-6Man, Man5-GlcNAc2-Asn 2.59* 2.32* 2.52*
MAL-II Siaα2-3Galβ1-4Glc(NAc)/Glc, SLex 0** 0** 0**
PTL-I GalNAc, GalNAcα-1, 3Gal, GalNAcα-1, 3Galβ-1,3/4Glc 6.63** 6.61*** 6.36**
SJA Terminal in GalNAc and Gal 3.61** 3.37** 3.01**
EEL Galα1-3(Fucα1-2)Gal 0.66 0.11*** 0.14***
LTL Fucα1-2Galβ1-4GlcNAc, Fucα1-3 (Galβ1-4) GlcNAc 0** 0** 0**
DBA GalNAcα-Ser/Thr(Tn) and GalNAcα1-3Gal 0* 0* 0*
RCA-120 β-Gal, Galβ-1, 4GlcNAc (type II), Galβ1-3GlcNAc (type I) 0.44** 0.46*** 0.39**
STL Trimers and tetramers of GlcNAc, core (GlcNAc) of N-glycan, oligosaccharide containing GlcNAc and MurNAc 0.35** 0.31** 0.33**
BS-I αGal and αGalNAc /** /*** /**
DSA β-D-GlcNA, (GlcNAcβ1-4)n, Galβ1-4GlcNAc 4.02*** 2.94 3.77***
SBA Terminal GalNAc (especially GalNAcα1-3Gal) 15.57*** 14.21*** 13.32***
UEA-I Fucoseα1-2Galβ1-4GlcNAc 8.00* 8.81*** 7.86***
BPL Galβ1-3GalNAc, terminal GalNAc /*** /*** /**
PHA-E+L Bisecting GlcNAc, biantennary N-glycans and tetraantennary complex-type N-glycan 8.80*** 11.52** 9.86**
  1. SCC squamous cell carcinoma
  2. /, the denominator of the fold change was zero
  3. *P < 0.05, **P < 0.01, ***P < 0.001