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Table 3 Differential protein expression profile

From: iTRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: biomarkers discovery

Accession Description Coverage Unique peptide Case/control P-value
P02042 Hemoglobin subunit delta OS=Homo sapiens GN=HBD PE=1 SV=2-[HBD_HUMAN] 67.35 3 1.46 0.0495
P02743 Serum amyloid P-component OS=Homo sapiens GN=APCS PE=1 SV=2-[SAMP_HUMAN] 33.18 8 1.25 0.0258
E5RHP7 Carbonic anhydrase 1 (Fragment) OS=Homo sapiens GN=CA1 PE=1 SV=1-[E5RHP7_HUMAN] 21.12 5 1.52 0.0356
I1VZV6 Hemoglobin alpha 1 OS=Homo sapiens GN=HBA1 PE=3 SV=1-[I1VZV6_HUMAN] 57.75 1 1.47 0.0467
Q6MZL2 Putative uncharacterized protein DKFZp686M0562 (Fragment) OS=Homo sapiens GN=DKFZp686M0562 PE=2 SV=1-[Q6MZL2_HUMAN] 29.6 7 1.21 0.0306
B4DF70 cDNA FLJ60461, highly similar to Peroxiredoxin-2 (EC 1.11.1.15) OS=Homo sapiens PE=2 SV=1-[B4DF70_HUMAN] 42.62 6 1.29 0.0346
P27348 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1-[1433T_HUMAN] 15.92 1 1.21 0.0320
H3BMH2 Ras-related protein Rab-11A (Fragment) OS=Homo sapiens GN=RAB11A PE=4 SV=1-[H3BMH2_HUMAN] 20.65 3 1.27 0.0487
A0A087WZR4 Low affinity immunoglobulin gamma Fc region receptor III-B OS=Homo sapiens GN=FCGR3B PE=1 SV=1-[A0A087WZR4_HUMAN] 12.5 1 1.35 0.0412
A0A075B6R9 Protein IGKV2D-24 (Fragment) OS=Homo sapiens GN=IGKV2D-24 PE=4 SV=1-[A0A075B6R9_HUMAN] 10.83 1 1.48 0.0385
Q99650 Oncostatin-M-specific receptor subunit beta OS=Homo sapiens GN=OSMR PE=1 SV=1-[OSMR_HUMAN] 1.74 2 1.20 0.0148
P80188 Neutrophil gelatinase-associated lipocalin OS=Homo sapiens GN=LCN2 PE=1 SV=2-[NGAL_HUMAN] 19.7 3 1.21 0.0144
A8K061 cDNA FLJ77880, highly similar to Homo sapiens angiopoietin-like 3, mRNA OS=Homo sapiens PE=2 SV=1-[A8K061_HUMAN] 10.43 5 1.21 0.0379
P24593 Insulin-like growth factor-binding protein 5 OS=Homo sapiens GN=IGFBP5 PE=1 SV=1-[IBP5_HUMAN] 2.94 1 1.61 0.0375
Q9UBG0 C-type mannose receptor 2 OS=Homo sapiens GN=MRC2 PE=1 SV=2-[MRC2_HUMAN] 2.16 3 1.30 0.0276
Q9GZP0 Platelet-derived growth factor D OS=Homo sapiens GN=PDGFD PE=1 SV=1-[PDGFD_HUMAN] 3.24 1 1.24 0.0093
Q7Z2Y8 Interferon-induced very large GTPase 1 OS=Homo sapiens GN=GVINP1 PE=2 SV=2-[GVIN1_HUMAN] 0.66 1 2.29 0.0133
P35754 Glutaredoxin-1 OS=Homo sapiens GN=GLRX PE=1 SV=2-[GLRX1_HUMAN] 10.38 1 1.47 0.0214
H7C070 Uncharacterized protein KIAA1109 (Fragment) OS=Homo sapiens GN=KIAA1109 PE=1 SV=1-[H7C070_HUMAN] 0.37 1 1.32 0.0150
Q53FL1 Tumor endothelial marker 8 isoform 3 variant (Fragment) OS=Homo sapiens PE=2 SV=1-[Q53FL1_HUMAN] 3.79 1 1.20 0.0185
H0YD18 Nucleobindin-2 (Fragment) OS=Homo sapiens GN=NUCB2 PE=1 SV=2-[H0YD18_HUMAN] 12.33 1 1.20 0.0143
M0R266 IgG receptor FcRn large subunit p51 (Fragment) OS=Homo sapiens GN=FCGRT PE=1 SV=1-[M0R266_HUMAN] 4.96 1 1.37 0.0164
B7Z3I9 Delta-aminolevulinic acid dehydratase OS=Homo sapiens PE=2 SV=1-[B7Z3I9_HUMAN] 3.19 1 1.27 0.0271
Q5T619 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1-[ZN648_HUMAN] 2.11 1 1.92 0.0407
B4E3Q1 cDNA FLJ61580, highly similar to Calsyntenin-1 OS=Homo sapiens PE=2 SV=1-[B4E3Q1_HUMAN] 1.35 2 1.33 0.0336
F6UYG0 Serine/threonine-protein kinase WNK1 OS=Homo sapiens GN=WNK1 PE=1 SV=1-[F6UYG0_HUMAN] 2.54 1 1.30 0.0051
A0A0J9YY48 Rab11 family-interacting protein 3 (Fragment) OS=Homo sapiens GN=RAB11FIP3 PE=4 SV=1-[A0A0J9YY48_HUMAN] 3.3 1 1.33 0.0384
P58166 Inhibin beta E chain OS=Homo sapiens GN=INHBE PE=1 SV=1-[INHBE_HUMAN] 2.29 1 1.32 0.0015
A0A024QZL1 Proteoglycan 1, secretory granule, isoform CRA_a OS=Homo sapiens GN=PRG1 PE=4 SV=1-[A0A024QZL1_HUMAN] 8.23 1 1.44 0.0119
B4E1S6 Syndecan OS=Homo sapiens GN=SDC4 PE=2 SV=1-[B4E1S6_HUMAN] 10.32 1 1.25 0.0010
C9J9F8 Coiled-coil domain-containing protein 173 (Fragment) OS=Homo sapiens GN=CCDC173 PE=4 SV=8-[C9J9F8_HUMAN] 3.8 1 1.71 0.00879
P01019 Angiotensinogen OS=Homo sapiens GN=AGT PE=1 SV=1-[ANGT_HUMAN] 43.71 1 0.68 0.0135
B4E1B3 cDNA FLJ53950, highly similar to Angiotensinogen OS=Homo sapiens PE=2 SV=1-[B4E1B3_HUMAN] 45.92 1 0.80 0.0144
B7Z8Q7 cDNA FLJ53871, highly similar to Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens PE=2 SV=1-[B7Z8Q7_HUMAN] 51.96 1 0.48 0.0001
B7Z9A0 cDNA FLJ56212, highly similar to Gelsolin OS=Homo sapiens PE=2 SV=1-[B7Z9A0_HUMAN] 45.43 1 0.71 0.0383
B3KS49 cDNA FLJ35478 fis, clone SMINT2007796, highly similar to Gelsolin OS=Homo sapiens PE=2 SV=1-[B3KS49_HUMAN] 51.55 1 0.56 0.0039
I3L145 Sex hormone-binding globulin OS=Homo sapiens GN=SHBG PE=1 SV=1-[I3L145_HUMAN] 75.58 17 0.82 0.0472
P0DOX2 Immunoglobulin alpha-2 heavy chain OS=Homo sapiens PE=1 SV=1-[IGA2_HUMAN] 46.15 5 0.71 0.0373
B2RBZ5 cDNA, FLJ95778, highly similar to Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (SERPINA10), mRNA OS=Homo sapiens PE=2 SV=1-[B2RBZ5_HUMAN] 40.54 1 0.80 0.0428
A0N5G3 Rheumatoid factor G9 light chain (Fragment) OS=Homo sapiens GN=V<lambda>3 PE=2 SV=1-[A0N5G3_HUMAN] 28.93 1 0.64 0.0082
A0A1B1CYC9 Vitamin D binding protein (Fragment) OS=Homo sapiens GN=Gc PE=4 SV=1-[A0A1B1CYC9_HUMAN] 40.63 6 0.47 0.0187
A0A0F7G8J1 Plasminogen OS=Homo sapiens GN=PLG PE=2 SV=1-[A0A0F7G8J1_HUMAN] 9.89 2 0.40 0.0005
P02675 Fibrinogen beta chain OS=Homo sapiens GN=FGB PE=1 SV=2-[FIBB_HUMAN] 19.55 7 0.80 0.0204
A8K430 Fructose-bisphosphate aldolase OS=Homo sapiens PE=2 SV=1-[A8K430_HUMAN] 23.35 6 0.71 0.0157
K7ELM3 Choriogonadotropin subunit beta variant 1 (Fragment) OS=Homo sapiens GN=CGB1 PE=3 SV=8-[K7ELM3_HUMAN] 49.61 5 0.24 0.0003
A0A0F7CSH9 Pregnancy-specific beta-1-glycoprotein 1 OS=Homo sapiens GN=PSG1 PE=2 SV=1-[A0A0F7CSH9_HUMAN] 14.11 2 0.45 0.0128
P11464 Pregnancy-specific beta-1-glycoprotein 1 OS=Homo sapiens GN=PSG1 PE=1 SV=1-[PSG1_HUMAN] 19.09 2 0.40 0.0212
A1L195 Tubulin beta chain (Fragment) OS=Homo sapiens GN=TUBB2B PE=2 SV=2-[A1L195_HUMAN] 22.87 2 0.73 0.0113
P01034 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1-[CYTC_HUMAN] 15.75 3 0.58 0.0022
Q6P988 Palmitoleoyl-protein carboxylesterase NOTUM OS=Homo sapiens GN=NOTUM PE=1 SV=2-[NOTUM_HUMAN] 14.31 5 0.52 0.0017
P22692 Insulin-like growth factor-binding protein 4 OS=Homo sapiens GN=IGFBP4 PE=1 SV=2-[IBP4_HUMAN] 5.43 1 0.65 0.0094
B3KPT3 cDNA FLJ32147 fis, clone PLACE5000116, highly similar to Homo sapiens thrombospondin, type I, domain containing 3 (THSD3), transcript variant 1, mRNA OS=Homo sapiens PE=2 SV=1-[B3KPT3_HUMAN] 5.18 2 0.36 0.0040
B3KV07 cDNA FLJ16013 fis, clone PLACE5000171, highly similar to Mus musculus sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1, mRNA OS=Homo sapiens PE=2 SV=1-[B3KV07_HUMAN] 2.88 2 0.56 0.0326
B4DTF1 cDNA FLJ51545, highly similar to Pregnancy-specific beta-1-glycoprotein 9 OS=Homo sapiens PE=2 SV=1-[B4DTF1_HUMAN] 20.16 4 0.39 0.0176
Q7Z7M8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 OS=Homo sapiens GN=B3GNT8 PE=1 SV=1 - [B3GN8_HUMAN] 5.04 1 0.81 0.0187
B7Z6V5 cDNA FLJ50240, highly similar to ADAM DEC1 (EC 3.4.24.-) (Adisintegrin and metalloproteinase domain-like protein decysin 1) OS=Homo sapiens PE=2 SV=1-[B7Z6V5_HUMAN] 3.84 1 0.72 0.0169
B4DEU9 cDNA FLJ50120, highly similar to Homo sapiens mannosidase, alpha, class 2A, member 2 (MAN2A2), mRNA OS=Homo sapiens PE=2 SV=1-[B4DEU9_HUMAN] 5.17 2 0.62 0.0018
C9J6H2 Insulin-like growth factor-binding protein 1 OS=Homo sapiens GN=IGFBP1 PE=1 SV=1-[C9J6H2_HUMAN] 6.48 1 0.53 0.0016
A0A1U9X793 APOM OS=Homo sapiens PE=4 SV=1-[A0A1U9X793_HUMAN] 25 1 0.70 0.0413
Q96SB0 Anti-streptococcal/anti-myosin immunoglobulin lambda light chain variable region (Fragment) OS=Homo sapiens PE=2 SV=1-[Q96SB0_HUMAN] 37.96 2 0.57 0.0322
A0A0A0MT36 Protein IGKV6D-21 (Fragment) OS=Homo sapiens GN=IGKV6D-21 PE=4 SV=1-[A0A0A0MT36_HUMAN] 10.53 1 0.70 0.0042
Q5NKU1 Intercellular adhesion molecule 3 (Fragment) OS=Homo sapiens GN=ICAM3 PE=2 SV=1-[Q5NKU1_HUMAN] 3.53 2 0.74 0.0140
B7Z1C5 Glutathione synthetase OS=Homo sapiens PE=2 SV=1-[B7Z1C5_HUMAN] 5.43 2 0.63 0.0377
Q5JRP2 Disintegrin and metalloproteinase domain-containing protein 12 (Fragment) OS=Homo sapiens GN=ADAM12 PE=1 SV=1-[Q5JRP2_HUMAN] 3.6 1 0.43 0.0136
B7Z9E9 cDNA, FLJ78813, highly similar to Homo sapiens abl-interactor 1 (ABI1), transcript variant 3, mRNA OS=Homo sapiens PE=2 SV=1-[B7Z9E9_HUMAN] 15 2 0.75 0.0250
Q96IE3 Similar to plectin 1, intermediate filament binding protein, 500kD (Fragment) OS=Homo sapiens PE=2 SV=1-[Q96IE3_HUMAN] 2.14 2 0.70 0.0337
Q9Y646 Carboxypeptidase Q OS=Homo sapiens GN=CPQ PE=1 SV=1-[CBPQ_HUMAN] 3.6 2 0.65 0.0051
B4DEU8 cDNA FLJ60233, highly similar to Liprin-alpha-3 OS=Homo sapiens PE=2 SV=1-[B4DEU8_HUMAN] 1.39 1 0.42 0.0009
P18065 Insulin-like growth factor-binding protein 2 OS=Homo sapiens GN=IGFBP2 PE=1 SV=2-[IBP2_HUMAN] 6.46 2 0.76 0.0230
B7Z8Y6 cDNA FLJ58394, highly similar to Platelet endothelial cell adhesion molecule OS=Homo sapiens PE=2 SV=1-[B7Z8Y6_HUMAN] 3.41 2 0.82 0.0120
B4DND4 cDNA FLJ50588, highly similar to Gamma-glutamyltransferase 5 (EC 2.3.2.2) OS=Homo sapiens PE=2 SV=1-[B4DND4_HUMAN] 2.2 1 0.40 0.0432
Q8TER0 Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=2 SV=2- [SNED1_HUMAN] 2.26 2 0.83 0.0155
B4E0T0 cDNA FLJ51589, highly similar to Neutrophil collagenase (EC 3.4.24.34) OS=Homo sapiens PE=2 SV=1-[B4E0T0_HUMAN] 4.26 1 0.59 0.0490
Q9HB00 Desmocollin 1, isoform CRA_b OS=Homo sapiens GN=DSC1 PE=4 SV=1 - [Q9HB00_HUMAN] 3.81 2 0.81 0.0314
A0A0B4J1R4 4-hydroxyphenylpyruvate dioxygenase OS=Homo sapiens GN=HPD PE=1 SV=1-[A0A0B4J1R4_HUMAN] 2.04 1 0.66 0.0341
P13727 Bone marrow proteoglycan OS=Homo sapiens GN=PRG2 PE=1 SV=2 - [PRG2_HUMAN] 4.95 1 0.43 0.0394
C9J3B7 Wiskott-Aldrich syndrome protein (Fragment) OS=Homo sapiens GN=WAS PE=1 SV=8-[C9J3B7_HUMAN 9.72 1 0.54 0.0010
A0A140TA77 Receptor-type tyrosine-protein phosphatase C (Fragment) OS=Homo sapiens GN=PTPRC PE=1 SV=1-[A0A140TA77_HUMAN] 2.41 1 0.74 0.0243