Table 3 STRING analysis of Molecular Function of Gene Symbol distributions from the TRYP and TRYP STYP where delta and χ2 were both greater than 9 after correction
#Term ID | Term description | Observed gene count | Background gene count | False discovery rate |
|---|---|---|---|---|
GO:0005488 | Binding | 1152 | 11878 | 9.77E−20 |
GO:0005515 | Protein binding | 694 | 6605 | 3.83E−13 |
GO:0005524 | ATP binding | 209 | 1462 | 1.30E−11 |
GO:0043167 | Ion binding | 637 | 6066 | 1.30E−11 |
GO:0032559 | Adenyl ribonucleotide binding | 213 | 1514 | 1.80E−11 |
GO:0008144 | Drug binding | 227 | 1710 | 3.62E−10 |
GO:0035639 | Purine ribonucleoside triphosphate binding | 232 | 1794 | 1.81E−09 |
GO:0032553 | Ribonucleotide binding | 238 | 1868 | 3.13E−09 |
GO:0032555 | Purine ribonucleotide binding | 236 | 1853 | 3.33E−09 |
GO:0097159 | Organic cyclic compound binding | 560 | 5382 | 3.33E−09 |
GO:1901363 | Heterocyclic compound binding | 552 | 5305 | 4.36E−09 |
GO:0097367 | Carbohydrate derivative binding | 265 | 2163 | 4.89E−09 |
GO:0000166 | Nucleotide binding | 258 | 2097 | 5.95E−09 |
GO:0008092 | Cytoskeletal protein binding | 130 | 882 | 5.00E−08 |
GO:0003779 | Actin binding | 76 | 413 | 6.27E−08 |
GO:0043168 | Anion binding | 309 | 2696 | 6.27E−08 |
GO:0016887 | ATPase activity | 73 | 392 | 7.90E−08 |
GO:0036094 | Small molecule binding | 282 | 2460 | 3.63E−07 |
GO:0042623 | ATPase activity, coupled | 60 | 320 | 1.76E−06 |
GO:0017111 | Nucleoside-triphosphatase activity | 111 | 778 | 3.30E−06 |
GO:0004386 | Helicase activity | 36 | 147 | 4.31E−06 |
GO:0016462 | Pyrophosphatase activity | 114 | 819 | 6.34E−06 |
GO:0046872 | Metal ion binding | 420 | 4087 | 6.91E−06 |
GO:0043169 | Cation binding | 425 | 4170 | 1.22E−05 |
GO:0003777 | Microtubule motor activity | 29 | 110 | 1.74E−05 |
GO:0008017 | Microtubule binding | 48 | 253 | 2.25E−05 |
GO:0051015 | Actin filament binding | 35 | 158 | 3.76E−05 |
GO:0019899 | Enzyme binding | 241 | 2197 | 9.02E−05 |
GO:0003774 | Motor activity | 30 | 131 | 0.00012 |
GO:0015631 | Tubulin binding | 55 | 344 | 0.00032 |
GO:0051020 | GTPase binding | 83 | 614 | 0.00064 |
GO:0017048 | Rho GTPase binding | 32 | 162 | 0.00073 |
GO:0003682 | Chromatin binding | 69 | 501 | 0.0018 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 19 | 76 | 0.0025 |
GO:0003676 | Nucleic acid binding | 330 | 3332 | 0.0028 |
GO:0005198 | Structural molecule activity | 86 | 679 | 0.0032 |
GO:0031267 | Small GTPase binding | 70 | 525 | 0.0036 |
GO:0004672 | Protein kinase activity | 81 | 635 | 0.0039 |
GO:0140096 | Catalytic activity, acting on a protein | 225 | 2176 | 0.005 |
GO:0019904 | Protein domain specific binding | 87 | 706 | 0.0061 |
GO:0005085 | Guanyl-nucleotide exchange factor activity | 46 | 311 | 0.0066 |
GO:0005509 | Calcium ion binding | 86 | 700 | 0.007 |
GO:0017016 | Ras GTPase binding | 66 | 510 | 0.0103 |
GO:0005516 | Calmodulin binding | 32 | 194 | 0.0106 |
GO:0004674 | Protein serine/threonine kinase activity | 59 | 444 | 0.011 |
GO:0051010 | Microtubule plus-end binding | 7 | 13 | 0.0119 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 37 | 243 | 0.0143 |
GO:0005096 | GTPase activator activity | 40 | 278 | 0.023 |
GO:0004004 | ATP-dependent RNA helicase activity | 15 | 66 | 0.0237 |
GO:0016773 | Phosphotransferase activity, alcohol group as acceptor | 89 | 767 | 0.0237 |
GO:0030695 | GTPase regulator activity | 43 | 307 | 0.0237 |
GO:0060589 | Nucleoside-triphosphatase regulator activity | 47 | 345 | 0.0237 |
GO:0044877 | Protein-containing complex binding | 108 | 968 | 0.0241 |
GO:0016772 | Transferase activity, transferring phosphorus-containing groups | 109 | 982 | 0.0255 |
GO:0032947 | Protein-containing complex scaffold activity | 15 | 68 | 0.0267 |
GO:0008047 | Enzyme activator activity | 63 | 510 | 0.0303 |
GO:0097493 | Structural molecule activity conferring elasticity | 7 | 17 | 0.0325 |
GO:0016301 | Kinase activity | 94 | 835 | 0.0352 |
GO:0051959 | Dynein light intermediate chain binding | 9 | 29 | 0.0352 |
GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | 5 | 8 | 0.0388 |
GO:0008094 | DNA-dependent ATPase activity | 14 | 66 | 0.0482 |
GO:0140030 | Modification-dependent protein binding | 22 | 131 | 0.0482 |
GO:0008026 | ATP-dependent helicase activity | 17 | 90 | 0.0499 |