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Table 3 (a) Functionally significant proteins increased in all stages of disease or in cancer stages (III, UII) (b) Functionally significant proteins decreased in all stages of disease or in both cancer stages (DDD, UDD). Significantly changed expression (± 1SD) in italic cells

From: Proteomics analysis of colon cancer progression

AccessionDescriptionGeneMW (kDa)Calc. pIMascot score# Peptides MascotCoverage %NAP/NC log2CC NM/NC log2CC M/NC log2
a
 Cell cycle progression, proliferation, DNA folding
  Q99459Cell division cycle 5-like proteinCDC5L92.1948.1841233.822.183.98
  Q8IX12Cell division cycle and apoptosis regulator protein 1CCAR1132.7395.76106332.162.162.42
  P49321Nuclear autoantigenic sperm proteinNASP85.1864.33005101.321.842.43
  P39687Acidic leucine-rich nuclear phosphoprotein 32 family member AANP32A28.5684.092322141.672.062.34
  Q92688Acidic leucine-rich nuclear phosphoprotein 32 family member BANP32B28.7704.063672142.152.763.09
  P09429High mobility group protein B1HMGB124.8785.7412549401.742.272.80
  P26583High mobility group protein B2HMGB224.0197.8110667251.712.092.89
  O15347High mobility group protein B3HMGB322.9658.374504281.431.742.52
  P17096High mobility group protein HMG-I/HMG-YHMGA111.66910.322132333.783.653.85
  Q969G3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1SMARCE146.6214.8856131.802.373.16
 Matrix degradation
  P83110Serine protease HTRA3HTRA348.5777.0961131.311.742.83
  P80188Neutrophil gelatinase-associated lipocalinLCN222.5748.914173231.342.143.18
  P24158MyeloblastinPRTN327.7898.356584281.263.793.50
  P02788LactotransferrinLTF78.1328.12354230491.722.524.19
  P14780Matrix metalloproteinase-9MMP978.4086.063586100.683.383.69
  O75173A disintegrin and metalloproteinase with thrombospondin motifs 4ADAMTS490.1397.8526110.601.902.90
  P08246Neutrophil elastaseELANE28.5009.35665842− 0.031.872.82
 Cytoskeletal remodelling
  Q8NF91Nesprin-1SYNE11010.4565.534130− 1.001.803.14
  Q16658FascinFSCN154.4967.24339614− 0.371.843.24
  P59998Actin-related protein 2/3 complex subunit 4ARPC519.6548.4389210− 0.231.612.54
  P55008Allograft inflammatory factor 1AIF116.6936.24566114− 0.192.042.69
  P05109Protein S100-A8S100A810.8287.0325828720.003.762.38
  P06702Protein S100-A9S100A913.2346.1366457630.194.052.45
  P13796Plastin-2LCP170.2445.43180315400.272.682.07
  P40121Macrophage-capping proteinCAPG38.4746.1913829350.332.003.07
  Q96SB3Neurabin-2PPP1R9B89.1384.9735110.691.733.42
  Q99439Calponin-2CNN233.6757.336685240.752.062.46
  Q12792Twinfilin-1TWF140.2586.96402120.802.042.35
  Q9UQB8Brain-specific angiogenesis inhibitor 1-associated protein 2BAIAP260.8308.973130.892.412.46
  Q13177Serine/threonine-protein kinase PAK 2PAK258.0065.961733161.091.882.23
 Immunity/inflammation
  P02671Fibrinogen alpha chaiFGA94.9146.0129481719− 0.572.363.84
  P02675Fibrinogen beta chainFGB55.8928.2749502861− 0.952.193.20
  P02679Fibrinogen gamma chainFGG51.4795.6223041849− 0.962.663.28
  P59665Neutrophil defensin 1DEFA110.1946.993582190.342.012.54
  P12838Neutrophil defensin 4DEFA410.4978.02541181.192.212.44
b
 Extracellular matrix
  Q96P44Collagen alpha-1(XXI) chainCOL21A199.3078.327611− 3.27− 5.81− 6.30
  P02462Collagen alpha-1(IV) chainCOL4A1160.5148.28148365− 2.70− 2.71− 2.94
  P39060Collagen alpha-1(XVIII) chainCOL18A1178.0776.0139532− 2.00− 3.09− 2.75
  P08572Collagen alpha-2(IV) chainCOL4A2167.4498.6619831312− 2.18− 2.71− 2.80
  P08123Collagen alpha-2(I) chainCOL1A2129.2358.95271498− 2.62− 2.44− 2.56
  P02452Collagen alpha-1(I) chainCOL1A1138.8575.80181499− 2.92− 1.95− 2.37
  Q05707Collagen alpha-1(XIV) chainCOL14A1193.3945.308942016− 2.52− 2.55− 2.16
  Q14031Collagen alpha-6(IV) chainCOL4A6163.7049.2013511− 0.61− 2.46− 3.94
  P12111Collagen alpha-3(VI) chainCOL6A3343.4576.682106810041− 1.81− 2.20− 2.44
  P12110Collagen alpha-2(VI) chainCOL6A2108.5126.2150182429− 2.15− 1.85− 1.99
  P12109Collagen alpha-1(VI) chainCOL6A1108.4625.4367692537− 1.87− 2.00− 2.09
  P20908Collagen alpha-1(V) chainCOL5A1183.4475.062922− 0.18− 2.20− 2.24
  Q16363Laminin subunit alpha-4LAMA4202.3976.284751210− 2.72− 2.05− 1.98
  O15230Laminin subunit alpha-5LAMA5399.4797.0217352811− 2.89− 3.34− 2.30
  P55268Laminin subunit beta-2LAMB2195.8546.5214512723− 2.88− 3.28− 2.42
  P13727Bone marrow proteoglycanPRG225.1896.76637530− 1.37− 2.85− 4.55
  Q6UVK1Chondroitin sulfate proteoglycan 4CSPG4250.3825.4713422− 1.14− 2.98− 2.95
  Q9Y2Y8Proteoglycan 3PRG325.3894.81222316− 0.33− 2.93− 2.41
  P07585Decorin 1DCN39.7228.5415741351− 2.66− 4.53− 3.85
  P21810BiglycanBGN41.6287.5218341146− 1.73− 1.91− 1.89
  P14543Nidogen-1NID1136.2915.299041517− 2.65− 2.98− 2.43
  Q14112Nidogen-2NID2151.1585.296401113− 1.56− 2.67− 2.23
  P35613BasiginBSG42.1745.66319518− 1.71− 2.02− 2.22
 Cell adhesion and plasma membrane integrity
  P08648Integrin alpha-5ITGA5114.4655.776781013− 2.26− 3.08− 3.34
  P05556Integrin beta-1ITGB188.3575.3930881625− 1.21− 2.18− 2.10
  P18084Integrin beta-5ITGB587.9966.0622534− 1.28− 2.18− 2.03
  P23229Integrin alpha-6ITGA6126.5266.61173923250.18− 2.21− 1.95
  P27216Annexin A13ANXA1335.3935.6025139− 1.57− 2.85− 3.33
  P20073Annexin A7ANXA752.7065.6822538− 1.69− 2.60− 2.85
  P08133Annexin A6ANXA675.8265.6032753050− 2.02− 1.96− 2.32
  P13688Carcinoembryonic antigen-related cell adhesion molecule 1CEACAM157.5255.9714826− 2.64− 4.05− 3.02
  Q14002Carcinoembryonic antigen-related cell adhesion molecule 7CEACAM729.3615.54335212− 2.05− 3.26− 3.91
  P09326CD48 antigenCD4827.6658.0790210− 1.39− 4.10− 4.48
  P13987CD59 glycoproteinCD5914.1686.48428425− 0.88− 1.78− 1.93
  P08962CD63 antigenCD6325.6197.817419− 0.48− 2.92− 3.25
  P60033CD81 antigenCD8125.7925.29184325− 1.27− 2.25− 2.68
  P21926CD9 antigenCD925.3997.154753210.09− 1.83− 2.53
  Q99795Cell surface A33 antigenGPA3335.6094.93694937− 0.72− 2.78− 3.35
  P04233HLA class II histocompatibility antigen gamma chainCD7433.4948.4429639− 0.17− 1.97− 2.60
  P28907ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1CD3834.3067.66302623− 0.21− 2.11− 2.29
  P04899Guanine nucleotide-binding protein G(i) subunit alpha-2GNA1240.4255.5412161036− 1.55− 3.17− 3.09
  Q9UBI6Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12GNG128.0018.9731126− 0.11− 2.76− 5.24
  P62873Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1GNB137.3536.00761626− 0.76− 3.82− 4.44
  P62879Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2GNB237.3076.00527626− 1.01− 3.37− 4.56
  P29992Guanine nucleotide-binding protein subunit alpha-11GNA1142.0975.69364315− 1.60− 1.79− 1.97
  Q14344Guanine nucleotide-binding protein subunit alpha-13GNA1344.0228.0052537− 1.43− 2.28− 3.42
  Q9HAV0Guanine nucleotide-binding protein subunit beta-4GNB437.5436.00116313− 2.70− 4.18− 4.28
 Excretion, transport of metabolites and modification of xenobiotics
  O75795UDP-glucuronosyltransferase 2B17UGT2B1761.0558.54895814− 6.21− 4.49− 5.67
  P40879Chloride anion exchangerSLC26A384.4518.699123− 4.01− 4.36− 4.89
  Q6UWM9UDP-glucuronosyltransferase2A3UGT2A360.2157.96234410− 3.83− 6.25
  Q14CN2Calcium-activated chloride channel regulator4CLCA4PE=11S0V1=.2195.4727456− 3.59
  P54289Voltage-dependent calcium channel subunit alpha-2/delta-1CACNA2D1124.495.275923− 2.55− 4.72− 4.82
  P50443Sulfate transporterSLC26A281.6098.3810224− 2.16− 2.58− 3.90
  Q96KA5Cleft lip and palate transmembrane protein 1-like proteinCLPTM1L62.1898.566838− 2.13− 3.85− 3.23
  O15438Canalicular multispecific organic anion transporter 2ABCC3169.2347.204611− 1.95− 2.72− 2.90
  Q15041ADP-ribosylation factor-like protein 6-interacting protein 1ARL6IP123.3479.322715− 1.69− 2.03− 2.63
  O14936Periphera plasma membrane protein CASKCASK105.0566.432811− 1.58− 1.97− 2.55
  P20020Plasma membrane calcium-transporting ATPase 1ATP2B1138.6686.0412354− 1.38− 2.29− 3.75
  P16662UDP-glucuronosyltransferase 2B7UGT2B760.6558.3161837− 1.36− 3.71− 4.13
  P10301Ras-related protein R-RasRRAS23.4666.93217315− 1.32− 3.18− 3.27
  Q8NE86Calcium uniporter protein, mitochondrialMCU39.8428.65181516− 1.32− 2.48− 3.15
  Q6UWW8Carboxylesterase 3CES362.2425.62137310− 0.46− 1.80− 1.91
  P23141Liver carboxylesterase 1CES162.4816.608124− 2.12− 1.78− 1.90
  P50225Sulfotransferase 1A1SULT1A134.1436.62187113− 3.21− 3.38− 4.38
  P0DMN0Sulfotransferase 1A4SULT1A434.1746.01240217− 0.97− 1.25− 3.23
  P07099Epoxide hydrolase 1EPHX152.9157.25280617− 2.41− 2.29− 2.42
  P37059Estradiol 17-beta-dehydrogenase 2HSD17B242.7578.505714− 2.52− 3.78− 3.76
  Q92506Estradiol 17-beta-dehydrogenase 8HSD17B826.9576.544024200.57− 1.91− 2.14
  P80365Corticosteroid 11-beta-dehydrogenase isozyme 2HSD11B244.0989.28453622− 2.35− 3.66− 4.13