Fig. 2
From: A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease
Pathways, network and upstream regulators analysis of the proteins increased or decreased in AD. a Canonical pathways were analyzed using IPA. The threshold for the top canonical pathways was set to –Log (p value) 4.5, and positive and negative z-scores are shown. b The most consistent protein network corresponds to cell-to-cell signalling-cellular assembly and organization-nervous system development and function. c Upstream regulators were investigated. γ, non-endogenous chemical drugs and toxicants were excluded. φ activation z-score was increased to 2. bias correction of the z-score is indicated. Green, proteins decreased in AD. Red, Proteins increased in AD