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Table 1 Biological processes classification of differential identified proteins in MSCs

From: Effects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells

Biological processes

Gene name

Differentiation

GATA6, DKK1, STC1, PDGFRB, COL5A2, FST, CCNB1, AURKA, TOP2A, INHBA, COL1A1, ANLN, JUN, SEMA7A, NCAM1, COL12A1, NRP2, FBN2, HGF

Immune system regulation process

TNFAIP3, KIF2C, PTX3, TMBIM1, IGHG1, JUN, NDRG1, NCAM1, MYO10, KIF22, COL1A1, RACGAP1, SEMA7A, KIF11, INHBA, MT2A, FST, C3, GEM, TOP2A, SERPINE1, KIF23, ANLN, PDCD1LG2, CRISPLD2, JUN

Wound healing and regeneration

TNFAIP3, SERPINB2, GATA6, MKI67, SERPINE1, F3, FOSL1, AURKA, COL1A1, DCN, NRP2, HGF, JUN, C3, PDGFRB, CCNB1, TFPI2, HIST2H3A, CCNA2

Apoptotic signaling pathway

BIRC5, STK17B, F3, TNFAIP3, SERPINE1, INHBA, TMBIM1, TIMP3, TOP2A, CHEK1, HGF, PDGFRB, TPX2, GATA6, SERPINB2, AURKA, CCNB1, TNFAIP3, NUAK1, FOSL1, AURKB, CPEB4, PLK1, JUN, ARAF, AMIGO2

Myeloid cell differentiation and ossification

INHBA, FBN2, STC1, COL5A2, JUN, HGF, COL1A1, SEMA7A

Oxidation resistance

TNFAIP3, PTX3, NDRG1, TIMP3, SERPINE1, COL1A1, NDRG1, STK17B,AURKA, PLK1, PDGFRB, CPEB4, AURKB, AMIGO2, TMBIM1, JUN, STC1, ARAF, GATA6, HGF, FOSL1, CCNB1, TOP2A, F3, CPEB4, BIRC5, SERPINB2, INHBA, CCNA2

Adaptive immune response

TNFAIP3, IGHG1, MYO10, DCN, C3, HGF, PDCD1LG2, JUN, SEMA7A, FST, INHBA, PTX3, TOP2A, SERPINE1, NCAM1, ANLN, MT2A

Inflammatory response

TNFAIP3, PTX3, SERPINE1, PDCD1LG2, SEMA7A, F3, HGF, C3

Interferon-gamma-mediated signaling pathway

PDCD1LG2, NCAM1, INHBA, MT2A

Cartilage development

STC1, BNC2, LUM, COL1A1, STC1, COL1A1, MEX3C

Regulation of cytokine production

GATA6, LUM, TNFAIP3, SERPINE1, PDCD1LG2, SEMA7A, INHBA, HGF, C3

Angiogenesis

SERPINE1, GATA6, PDGFRB, F3, JUN, HGF, NRP2, C3

Antigen processing and presentation

RACGAP1, TNFAIP3, CCNA2, KIF22, INHBA, KIF11, KIF2C, KIF23

Cell migration

F3, STC1, SERPINE1, SMURF2, DCN, COL1A1, PDGFRB, HGF, NRP2, JUN

Transforming growth factor beta1 production

GATA6, COL1A1, C3, LUM, JUN, SERPINE1, TNFAIP3, PDCD1LG2, SEMA7A, HGF, INHBA

Response to growth factor

PDGFRB, GATA6, NRP2, DKK1, SHCBP1, SHCBP1, CCNA2, SMURF2, COL1A1, SMURF2, JUN, FBN2, HGF, DCN, LUM

Aging

CHEK1, SERPINE1, AURKB, PDGFRB, DCN, JUN

Regulation of endothelial cell proliferation

SERPINE1, GATA6, DCN, TNFAIP3, THBS2, HGF, F3, C3, JUN, NRP2

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Clinical Proteomics

ISSN: 1559-0275