Table 2 Overview of the number of detected phosphopeptides by MS-based phosphoproteomics in colorectal cancer tissue samples, including the number of phosphopeptides that significantly change with CIT (p < 0.01)
Number of patients | 3 | ||||||||
Number of samples | 12 | ||||||||
Total number of peptides | 10,488 | ||||||||
Average number of peptides per sample | 6,044 | FC > 2 | FC > 3 | ||||||
T0 versus T60 | 28 (0.46%) | Up | 18 | 15 (0.25%) | Up | 10 | 4 (0.07%) | Up | 3 |
Down | 10 | Down | 5 | Down | 1 | ||||
T0 versus T120 | 48 (0.79%) | Up | 23 | 31 (0.51%) | Up | 15 | 16 (0.26%) | Up | 7 |
Down | 25 | Down | 16 | Down | 9 | ||||
T0 versus T180 | 52 (0.86%) | Up | 31 | 23 (0.38%) | Up | 15 | 13 (0.22%) | Up | 7 |
Down | 21 | Down | 8 | Down | 6 | ||||
Overlap between time points | 2 (0.03%) | Up | 1 | 1 (0.02%) | Up | 0 | 1 (0.02%) | Up | 0 |
Down | 1 | Down | 1 | Down | 1 | ||||
Number of peptides at T = 0* | 2715 | ||||||||
Unstable peptides compared to T = 0 | 90 (3.3%) |