Table 4 Student’s t-test analysis of tear proteome from patients diagnosed with pterygium versus control
Gene name | Protein | p-value | FDR 5% | FDR 1% | FWER | Control average LFQ log transformed | Pterygium average LFQ log transformed | SE of difference |
|---|---|---|---|---|---|---|---|---|
KRT13 | Keratin, type I cytoskeletal 13 | 1.16E−04 | Y | N | Y | 25.1 | 29.1 | 0.7 |
KRT14 | Keratin, type I cytoskeletal 14 | 3.27E−04 | Y | N | N | 25.1 | 28.4 | 0.7 |
RPL11 | 60S ribosomal protein L11 | 1.76E−03 | N | N | N | 20.0 | 22.3 | 0.3 |
KRT5 | Keratin, type II cytoskeletal 5 | 3.60E−03 | N | N | N | 26.7 | 29.3 | 0.7 |
UPK3BL; POLR2J3 | Uroplakin-3b-like protein | 6.69E−03 | N | N | N | 22.9 | 24.6 | 0.5 |
KRT6B | Keratin, type II cytoskeletal 6B | 8.21E−03 | N | N | N | 25.7 | 27.9 | 0.7 |
S100A8 | Protein S100-A8 | 8.43E−03 | N | N | N | 22.4 | 25.0 | 0.8 |
YWHAQ | 14–3-3 protein theta | 8.43E−03 | N | N | N | 21.1 | 22.9 | 0.4 |
ST13; ST13P4 | Hsc70-interacting protein; Putative protein FAM10A4 | 1.12E−02 | N | N | N | 22.1 | 22.6 | 0.1 |
FLG2 | Filaggrin-2 | 1.18E−02 | N | N | N | 20.7 | 24.6 | 1.2 |
S100A6 | Protein S100-A6 | 1.53E−02 | N | N | N | 23.5 | 26.1 | 0.9 |
KRT4 | Keratin, type II cytoskeletal 4 | 1.93E−02 | N | N | N | 25.4 | 27.6 | 0.8 |
HSPA8 | Heat shock cognate 71 kDa protein | 2.45E−02 | N | N | N | 22.0 | 23.7 | 0.6 |
MYL6; MYL6B | Myosin light polypeptide 6; Myosin light chain 6B | 2.49E−02 | N | N | N | 22.1 | 23.6 | 0.6 |
ANXA2; ANXA2P2 | Annexin A2; Annexin; Putative annexin A2-like protein | 2.79E−02 | N | N | N | 25.1 | 26.6 | 0.6 |
UBC§ | Polyubiquitin-C | 3.26E−02 | N | N | N | 22.2 | 24.7 | 1.1 |
IGHV5-10–1 | Immunoglobulin heavy variable 5–10-1 | 3.41E−02 | N | N | N | 21.9 | 23.1 | 0.5 |
CDC42 | Cell division control protein 42 homolog | 3.88E−02 | N | N | N | 21.1 | 22.1 | 0.4 |
YWHAZ | 14–3-3 protein zeta/delta | 4.12E−02 | N | N | N | 24.7 | 26.4 | 0.7 |
P4HB | Protein disulfide-isomerase | 4.87E−02 | N | N | N | 21.9 | 23.0 | 0.5 |