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Fig. 4 | Clinical Proteomics

Fig. 4

From: Evaluation of the potential of Pap test fluid and cervical swabs to serve as clinical diagnostic biospecimens for the detection of ovarian cancer by mass spectrometry-based proteomics

Fig. 4

Cellular localization and molecular function of the proteins identified in the three biospecimens. a Stacked bar chart of the cellular localization of the proteins identified in the biospecimens from the ovarian cancer patient based on their GO annotation. The cellular localization of the proteins identified in the Pap test fluid (Pap), the cervical swab (Swab), and the tumor tissue (Tumor) is shown. The percentage of proteins in each of the GO categories is shown. From the bottom: cytoplasm (blue), intracellular organelles (brown), nuclear (green), extracellular (purple) plasma membrane (light blue) cytoskeleton (orange). Proteins which could not be assigned to a GO category (unknown) made up less than 20 percent of the proteins from each biospecimen and were excluded from the analysis. b Bar chart showing the PANTHER Protein Class ontologies of the proteins identified in biospecimens from an ovarian cancer patient based on the percentage of proteins mapped to a Gene ID in PANTHER. For each biospecimen: Pap test fluid (Pap test, green), 897 proteins; cervical swab (Swab, orange), 1214 proteins, and tumor tissue (Tumor, blue), 2755 proteins were used to assign PANTHER Protein Class ontology categories. PANTHER Protein Classes comprising less than 1% of proteins in all three biospecimens are not shown

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Clinical Proteomics

ISSN: 1559-0275