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Fig. 1 | Clinical Proteomics

Fig. 1

From: Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan

Fig. 1

Proteomics workflow and analysis of recurrent and non-recurrent hepatocellular carcinoma (HCC) tumour explant samples obtained at the time of transplantation. A Schematic diagram of the proteomics workflow including the 11 HCC samples. B Proteomics analysis workflow to identify the most significant proteins between recurrent and non-recurrent HCC. C Volcano plot illustrating proteins differentially expressed (p < 0.05) in recurrent vs non-recurrent HCC tumors. Proteins in red are significantly increased in recurrent, while those in blue are significantly decreased in the recurrent cases. The three proteins bolded and marked with stars (ALDH1A1, LGALS3 and LGALS3BP) were subsequently selected for validation. Some protein names were removed for clarity, to minimize overlap. HCC, hepatocellular carcinoma; SCX, strong cationic exchange; LC, liquid chromatography; MS/MS, tandem mass spectrometry; ALDH1A1, retinal dehydrogenase 1, LGALS3, galectin-3; LGALS3BP, galectin-3-binding protein

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Clinical Proteomics

ISSN: 1559-0275