Table 1 General characteristics of the study subjects
Characteristics | For discovery | For validation | ||||
|---|---|---|---|---|---|---|
Cases | Controls | p | Cases | Controls | p | |
N | 10 | 10 | 31 | 33 | ||
Maternal age (years) | 29 (25–33) | 29.5 (25–34) | NS | 31.9 (25–38) | 31.4 (26–36) | NS |
Maternal BMI | 20.5 (19.0–26.5) | 20.9 (17.8–25.5) | NS | 21.6 (15.6–27.2) | 21.7 (18.0–28.6) | NS |
Periconceptional folic acid supplementation | 6 (60.0%) | 4 (40.0%) | NS | 21 (67.7%) | 16 (48.5%) | NS |
History of adverse pregnancy outcomes* | 2 (20.0%) | 3 (30.0%) | NS | 18 (58.1%) | 8 (24.2%) | 0.006 |
Caesarean delivery | 7 (70.0%) | 4 (40.0%) | NS | 22 (71.0%) | 15 (45.5%) | 0.039 |
Sex of infant (Female/male) | 5/5 | 5/5 | NS | 13/18 | 15/18 | NS |
Gestational age (days) | 277.6 (271–289) | 276.7 (262–290) | NS | 275.3 (243–301) | 276.8 (259–294) | NS |
Birth weight of infant (g) | 3547 (3100–3800) | 3304.4 (2500–3700) | NS | 3108.2 (1640–4040) | 3350 (2600–3980) | 0.03 |
Length of infant (cm) | 50.9 (48–53) | 49.9 (46–51) | NS | 49.3 (43–54) | 49.9 (46–53) | NS |