Fig. 3

Bioinformatics analysis of differentially expressed proteins. A Differential proteins are presented by the volcano plot. The vertical dotted lines represent proteins with a more than 1.5-fold increase (marked with red) or decrease (marked with blue), respectively. The gray dots are considered as no significant change, and horizontal dotted lines display cutoff P-value. B Heat map visualization of 69 differential proteins. The increased and decreased proteins are represented by a range of red and blue intensities, respectively